To observe the clinical efficacy of acupuncture in the treatment of anorexia nervosa with cancer by regulating Du meridian and strengthening spleen, and to explore the mechanism of its action.
The cases were included from October 2022 to June 2024, and 80 patients with anorexia nervosa with carcinoma attending the Department of Medical Oncology of the hospital were divided into the conventional group and the acupuncture group, each with 40 cases, using the random number table method. The conventional group was treated with conventional treatment of tumor, and the acupuncture group was treated with the acupuncture method of regulating Du meridian and strengthening spleen on the basis of the conventional treatment of tumor, and was treated continuously for 6 weeks. Body mass, quantitative appetite scale (NRS) scores, functional assessment of anorexia/malassemia treatment (FAACT) scores and traditional Chinese medicine syndrome scores and the levels of tumour necrosis factor-alpha (TNF-α), haemoglobin, albumin, interleukin-6 (IL-6), orexin A and leptin were compared between the two groups before and after treatment for 3 and 6 weeks and the clinical effect was evaluated.
Before treatment, the differences in body mass, NRS scores, traditional Chinese medicine syndrome scores and FAACT scores were not statistically significant between two groups (P>0.05). Comparing 3 and 6 weeks of treatment with the pre-treatment period, the body mass and FAACT scores of the two groups increased, and the traditional Chinese medicine syndrome scores and NRS scores decreased (P<0.05). Comparing 3 and 6 weeks of treatment, the two groups had higher body mass and FAACT scores and lower traditional Chinese medicine syndrome scores and NRS scores than the conventional group (P<0.05). The differences in haemoglobin, albumin, TNF-α, IL-6, orexigenin A and leptin were not statistically significant between the two groups compared with those before treatment (P>0.05). Comparing 3 and 6 weeks of treatment with pre-treatment, the levels of haemoglobin, orexin A, albumin increased and TNF-α, IL-6 and leptin decreased in both groups (P<0.05) and those levels in the acupuncture group were significantly lower compared with those in the conventional group (P<0.05). The total effective rate of the acupuncture group (87.50%) was higher than that of the conventional group (67.50%), and the difference was statistically significant (P<0.05).
Acupuncture treatment of cancerous anorexia nervosa with the method of regulating Du meridian and strengthening spleen improves the nutritional status of the body and enhances the therapeutic efficacy, which may be related to the regulation of the neuro-endocrine network.
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |