Full
Outline
To investigate the effects of Ginkgo biloba extract on the inflammatory response in the rats with ulcerative colitis (UC) based on the Toll-like receptor 4 (TLR4) /nuclear factor-κB (NF-κB) signaling pathway.
Forty SD rats were divided model group, Ginkgo biloba extract low-dose group, Ginkgo biloba extract high-dose group and normal group, each with 10 rats. The levels of interleukin (IL) -1 β, IL-6 and tumor necrosis factor (TNF) -α were measured using the Enzyme linked immunosorbent assay (ELISA) method. The expressions of TLR4 and NF-κB proteins in colon tissue was assessed via Western blot (WB). The Disease Activity Index (DAI), colon length, colon mucosal damage index (CMDI), inflammatory factors, TLR4 and NF-κB protein expressions were compared among the groups.
The DAI score, colon mucosal damage index (CMDI) score, the protein gray values of IL-1β, IL-6, TNF-α, TLR4 and NF-κB in the model group, Ginkgo biloba extract low-dose group and Ginkgo biloba extract high-dose group were higher than those of the normal group, while the colon length was shorter than that of the normal group (P<0.05). The DAI score, CMDI score, the protein gray values of IL-1β, IL-6,TNF-α, TLR4 and NF-κB of the Ginkgo biloba extract low-dose and high-dose groups were lower than those of the model group, while the colon length was longer than that of the model group (P<0.05). The DAI score, CMDI score, the protein gray values of IL-1β, IL-6, TNF-α, TLR4 and NF-κB of the Ginkgo biloba extract high-dose group were lower than those of the Ginkgo biloba extract low-dose group, while the colon length was longer than that of the low-dose Ginkgo biloba extract group (P<0.05).
Ginkgo biloba extract can alleviate the inflammatory response in the UC rats, and its mechanism may be related to the regulation of TLR4/NF-κB signaling pathway expression.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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