To analyze the effects of Jiawei Huanglian Ejiao Decoction (加味黄连阿胶汤) on TCM syndrome scores, plasma levels of interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α), neuron-specific enolase (NSE) and sleep quality in the patients with sleep disorder after stroke.

One hundred and twenty patients with post-stroke sleep disorder admitted to the hospital from March 2021 to May 2023 were randomly divided into the combined group (60 cases) and the control group (60 cases). The two groups were treated with conventional drugs and transcranial magnetic stimulation, and the combined group was treated with Jiawei Huanglian Ejiao Decoction. Both groups were treated for 6 weeks. The TCM syndrome scores, plasma levels of IL-10, TNF-α and NSE and sleep quality of the two groups before and after treatment were compared, and the clinical value of the two treatment schemes was analyzed.

After 6-week treatment, the scores of symptoms such as soreness and weakness of the lower back knee, feverish sensation, dry mouth and throat, hot flashes and night sweats in both groups decreased compared with those before treatment, the scores of TCM syndromes in the combined group were lower than those in the control group, and the difference was statistically significant (P<0.05). After 6 weeks of treatment, the plasma IL-10 levels in the two groups increased, while the levels of TNF-α and NSE decreased, and the plasma IL-10 in the combined group was higher than that in the control group, and the levels of TNF-α and NSE were lower than those in the control group, with statistical significance (P<0.05). After 6 weeks of treatment, the scores of each factor and the total score of Pittsburgh sleep quality index (PSQI) scale in both groups decreased compared with those before treatment. The scores of all factors and the total score of PSQI in the combined group were lower than those in the control group, and the difference was statistically significant (P<0.05).

On the basis of routine drug treatment, Jiawei Huanglian Ejiao Decoction can improve the TCM syndrome score of the patients with sleep disorder after stroke, regulate the inflammatory reaction and promote the recovery of neurological function, which has a positive impact on the improvement of sleep quality of patients.