To study the effect of Huatan Huoxue Tongluo Decoction (化痰活血通络汤) on unstable angina pectoris of coronary heart disease and its effect on the serum levels of cardiac troponin I (cTnI) and N-terminal pro-brain natriuretic peptide (NT-proBNP).

From January 2022 to December 2023, 100 patients with unstable angina pectoris of coronary heart disease treated in the hospital were selected and randomly divided into two groups, with 50 cases in each group. The control group was treated with enteric-coated aspirin and isosorbide dinitrate, while the observation group was additionally treated with Huatan Huoxue Tongluo Decoction on the basis of the control group. After 4 weeks of treatment, the TCM syndrome scores, angina attack conditions, cardiac function indicators, the serum levels of cTnI and NT-proBNP and medication safety were compared between the two groups.

After treatment, the TCM syndrome scores for chest tightness and heartache, shortness of breath and wheezing and palpitations with easy sweating significantly decreased in both groups, with the observation group showing greater improvement than the control group (P<0.05). After treatment, the Seattle Angina Questionnaire scores, the frequency of angina attacks and the duration of attacks decreased in both groups, with the observation group outperforming the control group (P<0.05). After treatment, both groups showed a significant reduction in left ventricular systolic and diastolic diameters and a significant increase in left ventricular ejection fraction, with the observation group outperforming the control group, and the difference was statistically significant (P<0.05). After treatment, the levels of cTnI and NT-proBNP decreased in both groups, with a more significant decrease in the observation group (P<0.05). No serious adverse reactions occurred in either group during the treatment process.

The effect of Huatan Huoxue Tongluo Decoction in the treatment of unstable angina pectoris of coronary heart disease is satisfactory. It can effectively improve the main TCM syndromes of the patients, relieve the angina pectoris, improve the cardiac function and the serum levels of cTnI and NT-proBNP. It is a safe and effective medication plan.