To study the clinical efficacy of Liumo Zengye Decoction (六磨增液汤) in the treatment of opioid-related constipation in patients with cancer pain.

A total of 86 cancer pain patients with opioid-related constipation treated in the hospital from January 2022 to May 2023 were included. According to the random number table method, they were divided into observation group and control group, with 43 patients in each group. The patients in the control group were treated with thunder fire moxibustion and acupoint application. The observation group was treated with Liumo Zengye Decoction combined with thunder fire moxibustion and acupoint application. The course of treatment was 14 days. The efficacy, TCM symptom scores, first defecation time after administration, disappearance time of abdominal pain and distension, toilet time, Chinese version of Constipation Patient Quality of Life Scale (PAC-QOL) score and adverse reactions were compared between the two groups.

The total effective rate of the observation group was 97.67%, which was significantly higher than that of the control group (81.40%) (P<0.05). After treatment, the scores of dry stool, red tongue, less body fluid and less moss and fatigue in the two groups were significantly decreased (P<0.05). After treatment, the scores of the above symptoms in the observation group were significantly lower than those in the control group (P<0.05). The first defecation time, abdominal pain and bloating disappearance time and toilet time in the observation group were significantly shorter than those in the control group (P<0.05). After treatment, the scores of each dimension and total score of PAC-QOL scale in the two groups were significantly decreased (P<0.05). After treatment, the scores of physiology, satisfaction and total score of PAC-QOL scale in the observation group were significantly lower than those in the control group (P<0.05), while the scores of social psychology and concern dimension were not significantly different from those in the control group (P>0.05). The incidence of adverse reactions in the observation group and the control group was 11.63% and 6.98%, respectively, and there was no significant difference between the two groups (P>0.05).

The clinical efficacy of Liumo Zengye Decoction combined with thunder fire moxibustion and acupoint application in the treatment of opioid-related constipation in the patients with cancer pain is satisfactory. It can better improve various symptoms, promote rapid recovery of the body, and improve the quality of life of the patients. It is a safe and effective treatment plan.