Shijianchuan (Salvia chinensia Benth) has various functions, including clearing heat and removing toxin, activating blood to relieve pain. It is commonly used in the treatment of hepatitis, nephritis, gynecological diseases and cancer. Recent research indicates that Shijianchuan (Salvia chinensia Benth) contains polysaccharides, terpenoids, sterols polyphenols and other compounds. These compounds contain various anti-tumor active ingredients, including polysaccharides and polyphenols from Shijianchuan (Salvia chinensia Benth), salvia chinensis, ursolic acid, quercetin and vanillin. Shijianchuan (Salvia chinensia Benth) has been found to inhibit the proliferation of malignant tumor cells such as breast cancer, gastric cancer, colon cancer, lung cancer and liver cancer. The mechanism of Shijianchuan (Salvia chinensia Benth) mainly involves inhibiting tumor cells proliferation, invasion and metastasis, inducing apoptosis and autophagy, blocking tumor cell cycle, inhibiting tumor angiogenesis, improving the immune function of the body, inhibiting the immune inflammatory response and synergistic sensitization to reverse tumor drug resistance. This article reviewed the anti-tumor mechanism of the active ingredients in Shijianchuan (Salvia chinensia Benth) and explored the current status of the anti-tumor research, with a view to providing reference basis for the in-depth study of Shijianchuan (Salvia chinensia Benth) anti-tumor and the development of new drugs.

Shijianchuan (Salvia chinensia Benth)  /  anti-tumor  /  mechanism  /  research progress