Full
Outline
To analyze the effect of Modified Huangqi Jianzhong Decoction (黄芪建中汤加减) combined with quadruple therapy on gastric motility and ulcer healing in patients with Helicobacter pylori (Hp) positive gastric ulcer of deficiency-cold in spleen-stomach type.
Two hundred patients with Hp-positive gastric ulcer of deficiency-cold in spleen-stomach type admitted to Henan Provincial Hospital of Traditional Chinese Medicine from July 2020 to June 2023 were divided into combined group (100 cases) and control group (100 cases) by simple random sampling. Both groups were treated with quadruple therapy, and the combined group was treated with Modified Huangqi Jianzhong Decoction for 2 months. The changes of gastric motility function, ulcer healing and TCM syndrome integral between the two groups before and after treatment were compared, and the Hp clearance rate, recurrence rate and clinical efficacy of the two groups were compared.
After treatment, the gastric emptying time, gastric antrum contraction frequency and gastric antrum-duodenum coordination in the two groups decreased, and the gastric antrum contraction amplitude increased. After treatment, the gastric emptying time, antrum contraction frequency and antrum-duodenum coordination in the combined group were lower than those in the control group, and the antrum contraction amplitude was higher than that in the control group (P<0.05). After treatment, the area of thick moss at the bottom of ulcer, the area of congestion of surrounding mucosa and the area of regenerative epithelium in the two groups decreased compared with those before treatment. And these indexes in the combined group were lower than those in the control group (P<0.05). After treatment, the main symptom score, secondary symptom score and total score of TCM syndromes in the two groups decreased compared with those before treatment and these indexes in the combined group were lower than those in the control group (P<0.05). The clearance rate and recurrence rate of Hp in the combined group were lower than those in the control group (P<0.05). After 2 months of treatment, the total effective rate of the combined group was higher than that of the control group (P<0.05).
On the basis of quadruple therapy, Modified Huangqi Jianzhong Decoction can not only promote the improvement of gastric motility and ulcer healing, but also be beneficial to reduce TCM syndrome scores, improve the Hp clearance rate, prevent the recurrence of Hp infection and improve the clinical efficacy.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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