To evaluate the effects of Siwu Decoction (四物汤) on endometrial thickness, blood flow resistance index (RI) and estrogen receptor (ER) expression in patients with endometrial hyperplasia.

A total of137 cases of endometrial hyperplasia patients treated from March 2022 to March 2024 were selected, and all patients were randomly divided into experimental group and control group. The experimental group was treated with Siwu Decoction, and the control group was treated with conventional treatment for 3 months. Endometrial thickness and blood flow RI were measured by ultrasonography. The expression of ER was detected by immunohistochemistry method. Serum estradiol (E2) levels were measured before and after treatment.

The endometrial thickness of the experimental group was significantly lower than that of the control group after treatment (P<0.05). The blood flow RI of the experimental group was significantly decreased and the blood flow was increased after treatment, which was better than that of the control group (P<0.05) . ER expression and E2 level in the experimental group were significantly decreased after treatment, and were lower than those in the control group (P<0.05). The menstrual cycle, menstrual volume and dysmenorrhea symptoms of the experimental group were significantly improved, and the differences were statistically significant compared with those of the control group (P<0.05) .

Siwu Decoction can effectively treat endometrial hyperplasia and relieve the clinical symptoms by adjusting endometrial thickness, improving hemodynamics and inhibiting estrogen receptor expression, and has significant clinical efficacy.