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Spacetime-Medicine Theory Illustrates Non-alcoholic Fatty Liver Disease on Traditional Chinese Medicine
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Xinru SHEN1, Chenyun MIAO1, Dongcheng LI2, Lin CHEN1, Xiaobing DOU1
Chinese Archives of Traditional Chinese Medicine | 2026, 44(5) : 189 - 192
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Chinese Archives of Traditional Chinese Medicine | 2026, 44(5): 189-192
• Target on National Project •
Spacetime-Medicine Theory Illustrates Non-alcoholic Fatty Liver Disease on Traditional Chinese Medicine
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Xinru SHEN1, Chenyun MIAO1, Dongcheng LI2, Lin CHEN1, Xiaobing DOU1
Affiliations
  • 1. School of Life Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China
  • 2. Global Chinese Medicine Education Center, Fort Lauderdale, 33304 USA
Published: 2026-05-10 doi: 10.13193/j.issn.1673-7717.2026.05.035
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The pathology of non-alcoholic fatty liver disease (NAFLD) is a dynamic process characterized by temporal and spatial dimensions. In the temporal dimension, NAFLD begins with liver dysfunction due to blockage by phlegm-dampness, progressing over time to the generation of pathological products such as blood stasis and turbid toxins, ultimately resulting in liver deficiency. In the spatial dimension, NAFLD evolves from affecting the liver and spleen to involving the liver, spleen, and kidneys, and may eventually spread to other organs in the body. The“multiple strikes”theory of NAFLD pathogenesis aligns with the spatial and temporal integration observed in traditional Chinese medicine (TCM) . The“first strike”of obesity and insulin resistance corresponds to spleen deficiency, dampness, and mitochondrial dysfunction. The“second strike”involves oxidative stress, lipid peroxidation in hepatocytes, turbid toxins accumulation in the liver, and endoplasmic reticulum stress, leading to liver-kidney yin deficiency. This paper aims to use the spacetime-medicine theory as a guide to bridge TCMwith modern life science, elucidating the TCMperspective on NAFLD's pathologic mechanism.

non-alcoholic fatty liver disease  /  spacetime-medicine theory  /  temporal dimension  /  spatial dimension  /  spacetime integration  /  molecular biological mechanisms
沈昕如, 缪晨韵, 李东成, 陈林, 窦晓兵. 从中医时空医学理论探究非酒精性脂肪性肝病. 中华中医药学刊, 2026 , 44 (5) : 189 -192 . DOI: 10.13193/j.issn.1673-7717.2026.05.035
Xinru SHEN, Chenyun MIAO, Dongcheng LI, Lin CHEN, Xiaobing DOU. Spacetime-Medicine Theory Illustrates Non-alcoholic Fatty Liver Disease on Traditional Chinese Medicine[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (5) : 189 -192 . DOI: 10.13193/j.issn.1673-7717.2026.05.035
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Year 2026 volume 44 Issue 5
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doi: 10.13193/j.issn.1673-7717.2026.05.035
  • Online Date：2026-10-14
  • Published：2026-05-10
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    1. School of Life Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China
    2. Global Chinese Medicine Education Center, Fort Lauderdale, 33304 USA
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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