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Research on Material Basis and Mechanism of Hongqi (Hedysari Radix) Regulating Immunity
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Lu WANG1, 2, Zimu YANG1, 2, Zhe PANG1, 2, Miaomiao YANG1, 2, Zhijia CUI1, 3, Jing SHAO1, 2, 3, 4, Shengfang WAN1
Chinese Archives of Traditional Chinese Medicine | 2026, 44(5) : 144 - 147
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Chinese Archives of Traditional Chinese Medicine | 2026, 44(5): 144-147
• Target on National Project •
Research on Material Basis and Mechanism of Hongqi (Hedysari Radix) Regulating Immunity
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Lu WANG1, 2, Zimu YANG1, 2, Zhe PANG1, 2, Miaomiao YANG1, 2, Zhijia CUI1, 3, Jing SHAO1, 2, 3, 4, Shengfang WAN1
Affiliations
  • 1. Gansu University of Chinese Medicine, Lanzhou 730000, Gansu, China
  • 2. Third Level Laboratory of the State Administration of Traditional Chinese Medicine (Key Laboratory of Traditional Chinese Medicine Chemistry), Lanzhou 730000, Gansu, China
  • 3. Northwest Collaborative Innovation Center for Traditional Chinese Medicine, Lanzhou 730000, Gansu, China
  • 4. Key Laboratory of Chemistry and Quality for Traditional Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu, China
Published: 2026-05-10 doi: 10.13193/j.issn.1673-7717.2026.05.027
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Hongqi (Hedysari Radix) is the commonly used herb in traditional Chinese medicine and its active ingredients include polysaccharides, saponins, flavonoids and organic acid. Pharmacological studies show that Hongqi (Hedysari Radix) has immunomodulatory, anti-inflammatory, gastrointestinal protective and antiviral effects. In the article, the immunomodulatory effects of Hongqi (Hedysari Radix) and its main active components were summarized and it reveals that Hongqi (Hedysari Radix) and its main active components can alleviate the inflammatory reaction and maintain the stability of the immune system by acting on the spleen, thymus, T and B lymphocytes, NK cells and macrophages. The mechanism of action may be reducing the expressions of inflammatory factors such as tumor necrosis factor-α (TNF-α), interleukin (IL) -2, IL-4, IL-6, IL-1 βand nuclear factor kappa-B (NF-κB), inhibiting pro-inflammatory factors and promoting the production of anti-inflammatory factors. Vitro experiments have shown that Hongqi (Hedysari Radix) and its extracts can improve oxidative stress and have target organ protective effects. In addition, Hongqi (Hedysari Radix) also has good immunomodulatory effects on autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus, which are caused by Th1/Th2 cytokine imbalance. This paper systematically summarized the main components of Hongqi (Hedysari Radix) with immunomodulatory effects and its action mechanism in immune regulation in order to provide basis for clinical application and further scientific research.

Hongqi (Hedysari Radix)  /  active ingredient  /  immunoregulation
王露, 杨子牧, 庞哲, 杨苗苗, 崔治家, 邵晶, 万生芳. 红芪的免疫调节活性成分及作用机制研究进展. 中华中医药学刊, 2026 , 44 (5) : 144 -147 . DOI: 10.13193/j.issn.1673-7717.2026.05.027
Lu WANG, Zimu YANG, Zhe PANG, Miaomiao YANG, Zhijia CUI, Jing SHAO, Shengfang WAN. Research on Material Basis and Mechanism of Hongqi (Hedysari Radix) Regulating Immunity[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (5) : 144 -147 . DOI: 10.13193/j.issn.1673-7717.2026.05.027
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Year 2026 volume 44 Issue 5
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doi: 10.13193/j.issn.1673-7717.2026.05.027
  • Online Date：2026-10-14
  • Published：2026-05-10
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    1. Gansu University of Chinese Medicine, Lanzhou 730000, Gansu, China
    2. Third Level Laboratory of the State Administration of Traditional Chinese Medicine (Key Laboratory of Traditional Chinese Medicine Chemistry), Lanzhou 730000, Gansu, China
    3. Northwest Collaborative Innovation Center for Traditional Chinese Medicine, Lanzhou 730000, Gansu, China
    4. Key Laboratory of Chemistry and Quality for Traditional Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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