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Outline
Cancer is still a major public health problem in the world, and it has become a serious threat to human health due to its refractory and high fatality rate. Traditional Chinese Medicine and its active ingredients have accumulated a lot of theoretical basis and practical experience in the treatment of malignant tumors. Bufalin is a cardiac glycoside compound isolated from the skin of Zhonghua Dachanchu (Bufo gargarizans) or Heikuang Chanchu (Bufo melanostictus) . Modern studies have proved that bufalin has broad-spectrum anti-cancer pharmacological activity against liver cancer, lung cancer, colorectal cancer, breast cancer and other tumors. Its anti-cancer mechanism mainly includes inhibition of tumor cell proliferation, invasion and metastasis, angiogenesis, cancer stem cancer, induction of apoptosis and autophagy, reversal of drug resistance, enhancement of chemotherapy sensitivity and immune function. The application and development of omics technology provide a new vision and strategy for studying the anti-tumor mechanism of bufalin. Therefore, this review included the latest research literature, updated the anti-cancer mechanism of bufalin, focused on the mechanism of genomics, transcriptomics, proteomics and metabolomics technology in the regulation of bufalin in the development of malignant tumors for the first time, and summarized the anti-cancer molecular mechanism of bufalin and the experimental results of traditional Chinese medicine based on related mechanisms and omics technology. The aim was to provide reference for further mechanism research and application of multiomics.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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