To investigate the clinical effect of Xinyue Capsule（心悦胶囊）combined with radial artery approach in the treatment of coronary artery disease.

In this study, 200 patients with coronary heart disease admitted from January 2022 to January 2024 were divided into two groups by random number table method, and were evenly divided into a single intervention group and a combined treatment group, with 100 cases in each group. The patients in the single intervention group received coronary intervention by radial artery approach. Those in the combined treatment group were treated with Xinyue Capsule combined with radial artery approach for coronary intervention. During the treatment process, 3 patients in the simple intervention group fell off（97 patients remained）, 4 patients in the combined treatment group fell off（96 patients remained）, and the data of patients in each group was compared, including the treatment effect, TCM syndrome effect, hemorheological indexes such as D-dimer and fibrinogen before and after treatment and left ventricular posterior wall thickness（LVPWT）, left ventricular ejection fractions（LVEF）, left ventricular end diastolic diameter（LVEF）, left ventricular end diastolic diameter, changes of cardiac function indexes such as left ventricular end diastolic diameter（LVEDD）, changes of serum N terminal proB type natriuretic peptide（NT-proBNP）, visualanalogue scale（VAS）and EuroQol five dimensions questionnaire（EQ-5D）.

The total effective rate of the combined treatment group was significantly higher than that of the simple intervention group（P<0.05）. After treatment, hemorheology indexes（D-dimer and fibrinogen, etc.）, cardiac function indexes（LVPWT, LVEF, LVEDD）, NT-proBNP level, VAS and EQ-5D scores of the patients in both groups were significantly improved. The theses indexes of the combined treatment group were all better than those of the simple intervention group（P<0.05）. The complication rate of the combined treatment group was lower than that of intervention group（P<0.05）.

The clinical effect of Xinyue Capsule combined with radial artery approach in the treatment of coronary artery intervention was relatively significant. After treatment, the patients＇ cardiac function was improved, the pain was relieved, the quality of life was improved, and the complications were reduced. The treatment is safe and reliable.