This study aims to assess the efficacy of Laonian Gusong Formula(老年骨松方)with calcitriol in treating the elderly patients with osteoporotic intertrochanteric fracture of the femur.
A total of 160 elderly patients with osteoporotic intertrochanteric fractures of the femur were enrolled at the Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine from February 2022 to February 2024. The patients were randomly divided into a treatment group(80 cases) receiving Laonian Gusen Formula combined with calcitriol and a control group(80 cases)receiving calcitriol alone. The treatment lasted for 2 months. The therapeutic efficacy, pain relief[visual analogue scale(VAS)], bone mineral density(BMD), bone metabolism markers[insulin-like growth factor-1(IGF-1), growth hormone(GH), bone gla protein(BGP)], daily living ability[Barthel index(BI)]and complication rates were monitored and evaluated.
The treatment group exhibited a significantly higher efficacy in traditional Chinese medicine syndrome treatment with a total effectiveness rate of 96.25%(77/80), compared to 77.50%(62/80)in the control group(P<0.05). Improvements in BI scores from 58.62 to 73.75 and reductions in VAS scores from 7.87 to 2.29 in the treatment group were significantly better than those in the control group(P<0.05). Furthermore, the bone density significantly increased in the treatment group, with the density measurements at the greater trochanter and femoral neck rising from 0.19 to 0.43 and from 0.43 to 0.49, respectively(P<0.000). Markers of bone metabolism such as IGF-1, GH and BGP also improved markedly(P<0.05). Additionally, the incidence of complications including pressure ulcers, infections and nausea was significantly lower in the treatment group at 5.00%(4/80)compared to 27.50%(22/80)in the control group(P<0.05).
The integration of Laonian Gusong Formula with calcitriol significantly enhances the bone density, alleviates the pain and promotes the functional recovery in the elderly patients with osteoporotic intertrochanteric fractures, proving to be an effective treatment strategy for these conditions.
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |