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Research Progress on Mechanism of Quercetin Against Acute Myeloid Leukemia
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Man ZHANG1, Qiuling MA1, 2, 3, 4, Mingxin LIU1, Jiayuan GUO1, Yajing SU1, Wenqing LIU1, Jue GUO1, Mingwei LI1, Bo WANG1, Wenbo DONG1, Dongdong LI2, Yi WU2, 3, 4
Chinese Archives of Traditional Chinese Medicine | 2026, 44(4) : 143 - 148
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Chinese Archives of Traditional Chinese Medicine | 2026, 44(4): 143-148
• Target on National Project •
Research Progress on Mechanism of Quercetin Against Acute Myeloid Leukemia
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Man ZHANG1, Qiuling MA1, 2, 3, 4, Mingxin LIU1, Jiayuan GUO1, Yajing SU1, Wenqing LIU1, Jue GUO1, Mingwei LI1, Bo WANG1, Wenbo DONG1, Dongdong LI2, Yi WU2, 3, 4
Affiliations
  • 1.The Second Clinical College of Medicine, Henan University of Chinese Medicine, Zhengzhou 450002, Henan, China
  • 2.Henan Provincial Hospital of Traditional Chinese Medicine, The Second Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450002, Henan, China
  • 3.Institute of Hematology, Henan University of Traditional Chinese Medicine, Zhengzhou 450002, Henan, China
  • 4.Henan Engineering Research Center of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Blood Diseases, Zhengzhou 450002, Henan, China
Published: 2026-04-10 doi: 10.13193/j.issn.1673-7717.2026.04.030
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Quercetin, as an active ingredient in traditional Chinese medicine, shows remarkable potential in the treatment of acute myeloid leukemia（AML）. Quercetin inhibits AML cell proliferation by regulating cell cycle proteins and indirectly regulates the cell cycle through heat shock proteins（HSP）and others. Quercetin induces apoptosis in AML cells by various mechanisms, such as regulating apoptotic protein expression, affecting mitochondrial function, inhibiting the phosphatidylin-ositol-3-kinase（PI3K）/protein kinase B（AKT）pathway and modulating the ERK and AMPK signaling pathways. Quercetin can affect AML through vascular endothelial growth factor（VEGF）expression.in AML cells, quercetin promotes cellular autophagy and affects autophagy key junctions and signaling pathways such as PI3K, hypoxia inducible factor-1 α（HIF-1 α）and mammalian target of rapamycin（mTOR）, but exhibits a protective effect in MV4-11. Quercetin exerts antioxidant damage and affects oxidative stress in AML by regulating nuclear factor erythroid 2-related factor 2（Nrf2）, nuclear factor kappa-B（NF-κB）and PI3K/AKT pathways. In addition, quercetin has epigenetic regulatory effects, inducing DNA demethylation, inhibiting HDAC activity and promoting histone H3 and H4 acetylation, thus inhibiting AML. This paper reviewed the therapeutic effects of quercetin on AML through multiple mechanisms, providing new strategies and directions for traditional Chinese medicine in the field of AML treatment.

acute myeloid leukemia  /  quercetin  /  research progress
张曼, 马秋玲, 刘洺欣, 郭家缘, 苏雅静, 刘文卿, 郭珏, 李明蔚, 王博, 董文博, 李东东, 吴艺. 槲皮素抗急性髓系白血病作用机制研究进展. 中华中医药学刊, 2026 , 44 (4) : 143 -148 . DOI: 10.13193/j.issn.1673-7717.2026.04.030
Man ZHANG, Qiuling MA, Mingxin LIU, Jiayuan GUO, Yajing SU, Wenqing LIU, Jue GUO, Mingwei LI, Bo WANG, Wenbo DONG, Dongdong LI, Yi WU. Research Progress on Mechanism of Quercetin Against Acute Myeloid Leukemia[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (4) : 143 -148 . DOI: 10.13193/j.issn.1673-7717.2026.04.030
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Year 2026 volume 44 Issue 4
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doi: 10.13193/j.issn.1673-7717.2026.04.030
  • Online Date：2026-10-14
  • Published：2026-04-10
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Affiliations
    1.The Second Clinical College of Medicine, Henan University of Chinese Medicine, Zhengzhou 450002, Henan, China
    2.Henan Provincial Hospital of Traditional Chinese Medicine, The Second Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450002, Henan, China
    3.Institute of Hematology, Henan University of Traditional Chinese Medicine, Zhengzhou 450002, Henan, China
    4.Henan Engineering Research Center of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Blood Diseases, Zhengzhou 450002, Henan, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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