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This study explored the pharmacological effect and mechanism of wogonin on lung metastasis of breast cancer after myocardial infarction, and provided potential drugs and experimental basis for the treatment of lung metastasis of breast cancer.
In the experiment, the mouse model of myocardial infarction and breast cancer was established by 6-7 weeks old female balb/c mice, and the effect of wogonin on lung metastasis of breast cancer after myocardial infarction and macrophages in mouse tumors was detected. THP-1, RAW264.7 and bone marrow-derived macrophages（BMDM）cells were induced in vitro to construct macrophage polarization model, and the effect of wogonin on macrophage polarization and the changes of key proteins regulating polarization were detected.
The results showed that compared with those of the model group, the number of lung tumor metastasis, the weight of breast tumor, cardiac function and cardiac inflammation were significantly reduced, and the expression of M2 macrophages in tumor was significantly reduced in the wogonin group. In vitro experiments showed that wogonin significantly inhibited the M2 polarization of macrophages, reduced the phosphorylation of signal transducer and activator of transcription 6（STAT6）and inhibited the migration of MDA-MB 231 cells.
The above results indicate that wogonin can inhibit the lung metastasis of breast adenocarcinoma after myocardial infarction, and its mechanism may be realized by inhibiting the phosphorylation of STAT6 and then affecting the M2 polarization of macrophages in the tumor.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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