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Outline
To explore the effects of Danggui Buxue Decoction（当归补血汤）combined with acupuncture on the levels of blood homocysteine（Hcy）, nerve growth factor（NGF）, insulin-like growth factor-1（IGF-1）and vascular endothelial growth factor（VEGF）and the changes in nerve conduction function in diabetic patients with peripheral neuropathy.
This paper collected 120 diabetic patients with peripheral neuropathy admitted to the hospital between January 2022 and January 2024, and were randomly divided into test group and control group. The control group used conventional Western medicine treatment, and the test group used acupuncture and Danggui Buxue Decoction. TCMsyndrome scores, diabetic peripheral neuropathy scores, diabetic neuropathy score（DNS）, clinical efficacy, serum levels of Hcy, NGF, IGF-1 and VEGF and nerve conduction function were compared.
There was no significant difference in TCMsyndrome scores, DNS, the serum levels of Hcy, NGF, IGF-1 or VEGF, the conduction velocities of median nerve motor conduction（MCV）and tibial nerve sensory conduction（SCV）between the two groups before treatment（P>0.05）. The scores of TCMsyndromes and DNS in both groups were significantly lower after treatment and the scores and DNS in the test group were significantly lower than those in the control group（P<0.05）. The clinical effective rate in the test group was significantly higher than that in the control group（P<0.05）. After treatment, the serum levels of Hcy and VEGF in the two groups were significantly lower than those before treatment, the serum levels of NGF and IGF-1, conduction velocities of MCV and SCV on both sides were significantly higher than those before treatment, and the decrease/increase amplitude in the test group was significantly higher than that in the control group（P<0.05）.
- Acupuncture and Danggui Buxue Decoction have obvious effect and can effectively improve the serum levels of Hcy, NGF, IGF-1 and VEGF and the nerve conduction function of the diabetic patients with peripheral neuropathy.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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