Full
Outline
To investigate the effect of Shengqing Jiangzhuo Capsule（升清降浊胶囊, SQJZC）on membranous nephropathy in rats and its specific mechanism.
The rat model of membranous nephropathy was established, and the rats were treated with different concentrations of SQJZC. Biochemical indicators were determined, including 24-hour proteinuria, blood urea nitrogen（BUN）, serum creatinine（SCR）, triglyceride（TG）, total cholesterol（TC）, alanine aminotransferase（ALT）and aspartate aminotransferase（AST）. Hematoxylin eosin（HE）and periodic acid silver amine（PASM）staining were conducted to observe the pathological changes of glomerulus. The related indexes of Wnt1/β-catenin signaling pathway were detected by Western blot.
After SQJZC treatment, the 24 h urine protein of the rats decreased（P < 0.05）. There were no significant changes in BUN, SCR, AST or ALT in each group. Compared with those in the model group, the levels of TC and TG in the SQJZC group decreased in some degrees（P < 0.05）. The pathological staining results showed that SQJZC could alleviate the glomerular capillary basement membrane thickening in rats. Western blot results showed that SQJZC could restore the expression of nephrin protein in renal tissue. Compared with those of the blank group, the expression levels of MMP-7, Cyclin D1, CTGF, Wnt1, c-Myc, β-catenin and active β-catenin in the model group were increased（P < 0.05）. Compared with those of the model group, the expression levels of MMP-7, Cyclin D1, CTGF, Wnt1, c-Myc, β-catenin and active β-catenin in the SQJZC group were decreased（P < 0.05）.
SQJZC could alleviate the renal injury in rats with membranous nephropathy, and its mechanism may be through Wnt1/β-catenin signaling pathway.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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