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Experimental Study on Inhibitory Pharmacological Effects of Morusin on RNA Polymerase of SARS-CoV-2 and Prediction of Activity of Related Analogs
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Qiaona WU1, Xiaohua XIE2, Jinglei LIU3, Yujia WANG4, Kun DI1, Yanlei SU3, Dianxing SUN3, Shan CEN4
Chinese Archives of Traditional Chinese Medicine | 2026, 44(3) : 67 - 69
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Chinese Archives of Traditional Chinese Medicine | 2026, 44(3): 67-69
• Target on National Project •
Experimental Study on Inhibitory Pharmacological Effects of Morusin on RNA Polymerase of SARS-CoV-2 and Prediction of Activity of Related Analogs
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Qiaona WU1, Xiaohua XIE2, Jinglei LIU3, Yujia WANG4, Kun DI1, Yanlei SU3, Dianxing SUN3, Shan CEN4
Affiliations
  • 1.The Third Hospital of Shijiazhuang, Shijiazhuang 050011, Hebei, China
  • 2.Hebei General Hospital, Shijiazhuang 050051, Hebei, China
  • 3.The 980th Hospital of The Joint Logistics Support Force of the Chinese People＇s Liberation Army, Shijiazhuang 050082, Hebei, China
  • 4.Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2026-03-10 doi: 10.13193/j.issn.1673-7717.2026.03.012
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Objective

To investigate the inhibitory pharmacological effects of Morusin on the function of the RNA polymerase of SARS-CoV-2, and the target enzyme inhibitory activity of 5 kinds of traditional Chinese medicine ingredients similar to mulberry sinin was predicted.

Methods

Molecular docking technology was used to study the binding mode of Morusin to the active site of the RNA polymerase of SARS-CoV-2. The inhibitory activity of Morusin on RNA polymerase was then tested using a cell-based RNA polymerase catalytic system. Five small molecules with structural analogs of morocinin were selected from the components of Morus traditional Chinese medicine, and their interaction patterns with amino acids at the active site of RNA polymerase were studied using molecular docking methods.

Results

Morusin can firmly occupy the NTPs channel of RNA polymerase and block the entry of nucleotides, thereby inhibiting the nucleic acid replication function of RNA polymerase. Pharmacological experiments at the cellular level confirmed that the inhibitory activity of Morusin on RNA polymerase was stronger than that of the control drug remdesivir. At the same time, the 5 kinds of small molecules of the structural analogs of mulberry can also bind to the active site of RNA polymerase and have enzyme inhibitory activity.

Conclusion

This study has found that Morusin has strong inhibitory activity on RNA polymerase, the five analogs are also predicted to have strong RNA polymerase inhibitory activity, and the results can provide a reference for the development of anti-SARS-CoV-2 drugs.

SARS-CoV-2  /  RNA polymerase  /  Morusin  /  molecular dock  /  pharmacological experiment  /  analogs
吴巧娜, 谢小华, 刘晶磊, 王宇佳, 邸琨, 苏彦雷, 孙殿兴, 岑山. 桑辛素对新型冠状病毒RNA聚合酶抑制作用的实验研究及相关类似物活性预测. 中华中医药学刊, 2026 , 44 (3) : 67 -69 . DOI: 10.13193/j.issn.1673-7717.2026.03.012
Qiaona WU, Xiaohua XIE, Jinglei LIU, Yujia WANG, Kun DI, Yanlei SU, Dianxing SUN, Shan CEN. Experimental Study on Inhibitory Pharmacological Effects of Morusin on RNA Polymerase of SARS-CoV-2 and Prediction of Activity of Related Analogs[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (3) : 67 -69 . DOI: 10.13193/j.issn.1673-7717.2026.03.012
Appendix
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Year 2026 volume 44 Issue 3
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Article Info
doi: 10.13193/j.issn.1673-7717.2026.03.012
  • Online Date：2026-10-14
  • Published：2026-03-10
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Affiliations
    1.The Third Hospital of Shijiazhuang, Shijiazhuang 050011, Hebei, China
    2.Hebei General Hospital, Shijiazhuang 050051, Hebei, China
    3.The 980th Hospital of The Joint Logistics Support Force of the Chinese People＇s Liberation Army, Shijiazhuang 050082, Hebei, China
    4.Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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https://castjournals.cast.org.cn/joweb/zhzyyxk/EN/10.13193/j.issn.1673-7717.2026.03.012
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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