Home Journals Articles Updates About
CN
image
收藏切换
Mechanisms of Linggui Zhugan Decoction（苓桂术甘汤）Interfering in PI3K/AKT Pathway to Affect Fatty Acid Metabolism in NAFLD Mice
收藏切换
Yuan ZHANG1, Zhuo YANG1, Yuan CAO2, Qun WANG2
Chinese Archives of Traditional Chinese Medicine | 2026, 44(3) : 50 - 54
Less
收藏切换
Chinese Archives of Traditional Chinese Medicine | 2026, 44(3): 50-54
• Target on National Project •
Mechanisms of Linggui Zhugan Decoction（苓桂术甘汤）Interfering in PI3K/AKT Pathway to Affect Fatty Acid Metabolism in NAFLD Mice
Full
Yuan ZHANG1, Zhuo YANG1, Yuan CAO2, Qun WANG2
Affiliations
  • 1.Chinese People＇s Liberation Army(PLA)General Hospital, Shenyang 110000, Liaoning, China
  • 2.Liaoning University of Traditional Chinese Medicine, Shenyang 110847, Liaoning, China
Published: 2026-03-10 doi: 10.13193/j.issn.1673-7717.2026.03.009
Outline
收藏切换
Objective

To investigate the effect of Linggui Zhugan Decoction（苓桂术甘汤）on lipid metabolism in mice with nonalcoholic fatty liver disease（NAFLD）, and to provide a new target and data support for clinical treatment of NAFLD.

Methods

C57BL/6J mice were used as the blank control group. ApoE-/- mice were divided into model group, Linggui Zhugan Decoction low, middle and high dose groups and simvastatin group. The blood lipid levels of mice were detected by automatic biochemical analyzer. Hematoxylin-eosin（HE）staining and oil red O staining were used to determine the degree of liver steatosis in NAFLD mice. RT-qPCR was used to detect the mRNA expressions of PI3K, AKT, FASN, SREBP1 and ATGL. The protein expressions of PI3K, AKT, p-AKT, FASN, SREBP1 and ATGL were detected by Western Blot.

Results

After treatment with Linggui Zhugan Decoction, the serum levels of total cholesterol（TC）, triglyceride（TG）and low-density lipoprotein cholesterol（LDL-C）were down-regulated（P < 0.05）. The expressions of fatty acid synthesis related genes and proteins FASN and SREBP1 were decreased（P < 0.05）, and the expressions of TG breakdown related genes and proteins ATGL were increased（P < 0.05）. The protein expressions of PI3K and p-AKT were significantly increased（P < 0.05）.

Conclusion

Linggui Zhugan Decoction may inhibit the occurrence and development of NAFLD by promoting the decomposition of hepatic triglyceride and inhibiting fatty acid synthesis through PI3K/AKT signaling pathway.

non-alcoholic fatty liver  /  Linggui Zhugan Decoction（苓桂术甘汤）  /  fatty acid synthesis  /  fatty acid decomposition
张援, 杨卓, 曹媛, 王群. 苓桂术甘汤干预PI3K/AKT通路影响脂肪酸代谢减缓小鼠非酒精性脂肪肝的机制研究. 中华中医药学刊, 2026 , 44 (3) : 50 -54 . DOI: 10.13193/j.issn.1673-7717.2026.03.009
Yuan ZHANG, Zhuo YANG, Yuan CAO, Qun WANG. Mechanisms of Linggui Zhugan Decoction（苓桂术甘汤）Interfering in PI3K/AKT Pathway to Affect Fatty Acid Metabolism in NAFLD Mice[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (3) : 50 -54 . DOI: 10.13193/j.issn.1673-7717.2026.03.009
Appendix
Less
Year 2026 volume 44 Issue 3
77
15
Cite this Article
BibTeX
Article Info
doi: 10.13193/j.issn.1673-7717.2026.03.009
  • Online Date：2026-10-14
  • Published：2026-03-10
Article Data
Affiliations
History
Funding
Affiliations
    1.Chinese People＇s Liberation Army(PLA)General Hospital, Shenyang 110000, Liaoning, China
    2.Liaoning University of Traditional Chinese Medicine, Shenyang 110847, Liaoning, China
References
Share
https://castjournals.cast.org.cn/joweb/zhzyyxk/EN/10.13193/j.issn.1673-7717.2026.03.009
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62662699(Operation and Technical Support)
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House