Taohe Chengqi Decoction（桃核承气汤），formulated by the medical sage ZHANG Zhongjing in the Treatise on Febrile Diseases（Shanghanlun），is composed of five herbs：Taoren（Persicae Semen），Dahuang（Rhei Radix et Rhizoma），Guizhi（Cinnamomi Ramulus），Mangxiao（Natrii Sulfas）and Zhigancao（Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle）. In this formula，Taoren（Persicae Semen）breaks blood stasis and promotes blood circulation，Dahuang（Rhei Radix et Rhizoma）purges heat and expels blood stasis，Mangxiao（Natrii Sulfas）softens hardness and clears heat，Guizhi（Cinnamomi Ramulus）invigorates blood and unblocks the channels，and Zhigancao（Glycyrrhizae Radix et Rhizoma Praeparata Cum Melle）protects the stomach and harmonizes the middle burner. Together，these herbs work synergistically to break up blood stasis and expel it downward. The main effects of this formula are to remove blood stasis and dispel heat. It is a representative formula highly regarded by later generations of physicians for its combined approach of promoting bowel movements to clear heat and promoting blood circulation for removing blood stasis. It is primarily used to treat blood stasis syndrome in the lower abdomen. It is mainly used to treat blood accumulation syndrome in the lower burner. Modern pharmacological studies have demonstrated that Taohe Chengqi Decoction has various effects，such as anti-inflammatory，anti-fibrotic，vascular-protective，and blood circulation-improving properties. Clinically，this formula is commonly used to treat gynecological diseases，neurological disorders，digestive system diseases，cardiovascular diseases and Inflammation-related diseases. Quality control research based on traditional Chinese medicine quality markers（Q-Markers）involves exploring the active ingredients and material basis of Taohe Chengqi Decoction through various technical theories and research methods to identify its characteristic components，thereby providing a more scientific and accurate quality control standard for its clinical application and experimental research. This article summarized the recent research progress on the chemical components，pharmacological effects and clinical applications of Taohe Chengqi Decoction. It predicted and analyzed the quality markers of this formula according to the concepts of transmission and traceability，specificity，effectiveness，compatibility in complex formulations and measurability in the Q-Marker framework. The results suggest that amygdalin，aloe-emodin，rhein，emodin，cinnamic acid，cinnamaldehyde，sodium sulfate，glycyrrhizin and glycyrrhizic acid can serve as the Q-Markers for Taohe Chengqi Decoction，providing a basis for its quality control.