Full
Outline
Liver fibrosis is a common chronic liver disease，which is easy to develop into cirrhosis and even liver cancer. Its morbidity and mortality are high. The pathogenesis has not been fully defined，and there are no specific drugs against liver fibrosis. Animal model experiments are commonly used in liver fibrosis research. Based on the clinical characteristics of liver fibrosis，this paper summarized and evaluated the existing animal models of liver fibrosis，providing references for improving the establishment of animal models of liver fibrosis combining disease and syndrome.
According to the clinical diagnostic criteria of traditional Chinese medicine（TCM）and Western medicine for liver fibrosis，the clinical characteristics of TCM and Western medicine were summarized，assigned and evaluated.
It was concluded that subcutaneous/intraperitoneal injection of CCl4 suspension modeling，intraperitoneal injection/free drinking of thionoacetamide modeling，caudal vein injection of hepatitis B virus modeling，subcutaneous injection of CCl4 solution + high-fat feed + ethanol solution drinking modeling were highly consistent with Western medicine，but were not well consistent with TCM. The coincidence between TCM and western medicine is good，and the coincidence between TCM and Western medicine is the highest.
The existing animal model of the combination of disease and syndrome has a high coincidence between TCM. and Western medicine. According to the syndrome type of traditional Chinese medicine，it is feasible to simulate the development and change of human liver fibrosis in animals and establish the corresponding animal model of liver fibrosis（healthy Qi deficiency，toxin accumulation and blood stasis type）. However，at present，the animal model of combining disease and syndrome still does not cover all syndrome types，and lacks the unified and standardized syndrome differentiation standards. Therefore，it is necessary to use the idea of combining TCM and Western medicine and modern biotechnology to establish a more suitable animal model of combining disease and syndrome with liver fibrosis on the basis of ensuring the accuracy and stability of the model，so as to provide a research basis for the treatment of liver fibrosis by combining TCM and Western medicine.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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