To observe the effects of Modified Liuwei Dihuang Decoction（六味地黄汤加味）combined with acupuncture on optic disc blood flow and visual function in patients with liver-kidney Yin deficiency syndrome of non-proliferative diabetic retinopathy（NPDR）.

Eighty-six patients with liver-kidney Yin deficiency syndrome of NPDR were randomly divided into control group and experimental group，each with 43 cases，using random number generation by Excel. Both groups received routine treatment，with the control group additionally receiving acupuncture treatment，and the experimental group receiving Modified Liuwei Dihuang Decoction based on the treatment of the control group. The changes in traditional Chinese medicine（TCM）symptom scores，optic disc blood flow and visual function before and after treatment in both groups were compared. The therapeutic effects and adverse reactions between the two groups were compared.

Two cases were lost to follow-up in each group，and ultimately 41 cases were included in both. After treatment，the main symptom scores，secondary symptom scores，total scores and best-corrected visual acuity（BCVA）in logarithm of the minimum angle of resolution（LogMAR）in the experimental group were higher than those in the control group（P<0.05），the blood flow density（PPVD）values at the temporal inferior，temporal superior，nasal superior，nasal inferior，inferior temporal，inferior nasal，superior nasal and inferior nasal quadrants were higher than those in the control group（P<0.05）. The total effective rate in the experimental group was higher than that in the control group（P<0.05）. There was no statistically significant difference in the incidence of adverse reactions between the control group and the experimental group（P>0.05）.

Modified Liuwei Dihuang Decoction combined with acupuncture can alleviate TCM symptoms of NPDR，improve optic disc blood flow，visual function and clinical efficacy，and does not lead to an increase in adverse reactions.