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Effects of Buzhong Yiqi Granules(补中益气颗粒)on Postpartum Repair,Levels of TGF-β3 and RLX in Women with Qi Deficiency Syndrome
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Wanjing HU, Yewei YE
Chinese Archives of Traditional Chinese Medicine | 2026, 44(1) : 93 - 97
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Chinese Archives of Traditional Chinese Medicine | 2026, 44(1): 93-97
• Target on National Project •
Effects of Buzhong Yiqi Granules(补中益气颗粒)on Postpartum Repair,Levels of TGF-β3 and RLX in Women with Qi Deficiency Syndrome
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Wanjing HU, Yewei YE
Affiliations
  • Wenzhou Hospital of Traditional Chinese Medicine, Wenzhou 325000, Zhejiang, China
Published: 2026-01-10 doi: 10.13193/j.issn.1673-7717.2026.01.020
Outline
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Objective

To analyze the promoting effect of Buzhong Yiqi Granules(补中益气颗粒)on postpartum repair of women with Qi deficiency syndrome,and analyze the influence on the expressions of transforming growth factorβ3(TGF-β3)and relaxin(RLX).

Methods

A total of 112 pregnant women with Qi deficiency syndrome who gave birth in the hospital from April 2021 to September 2022 were selected and divided into control group and study group with 56 cases in each. In the control group,postpartum women received intravenous injection of oxytocin,while rehabilitation therapy equipment and acupoint massage were used to assist in recovery for 5 consecutive days. In the study group,Buzhong Yiqi Granules were added,3 g/time,2-3 times/day,continuous intervention for 5 days. The postpartum recovery of the two groups(postpartum time of uterine entry into the pelvis,disappearance time of lochia rubra,daily descending height of fundus),lactation function,breastfeeding rate,breast comfort,uterine degeneration,pelvic floor function,syndrome score,hormone level,TGF-β3,RLX and other indicators were compared.

Results

Compared with those of the control group,the time of uterine entry into the pelvis,the time of lochia rubra dripping disappearance in the study group were shortened[(5.32±0.57)d vs(6.83±1.10)d,(4.64±1.23)d vs(7.44±2.04)d],and the daily descending height of fundus was shortened was higher than that of the control group[(4.01±1.20)cm vs(2.33±0.95)cm](t=9.121,8.796,8.214,P<0.05). Lactation onset time in the study group was shorter than that in the control group[(16.52±7.83)h vs(22.57±4.48)h],lactation volumes were higher than those in the control group[24 h postpartum:(46.59±4.76)mL vs(35.52±3.74)mL,72 h postpartum:(133.51±11.05)mL vs(116.48±10.49)mL](t=5.019,13.680,8.369,P<0.05). Breast comfort of the study group was better than that of the control group[breast tenderness free:44.64% vs 12.50%,breast hardnessⅠ:51.79% vs 19.64%](Z=18.980,18.440,P<0.05). After treatment,in the study group,the sum of three diameters of uterus,the resistance index and the pulsation index were lower than those of the control group[(237.42±11.55)mm vs(271.59±10.12)mm,1.86±0.15 vs 2.12±0.17,0.59±0.04 vs 0.77±0.08](t=16.650,15.060,8.582,P<0.05). After treatment,the peak systolic flow velocity in the study group was higher than that in the control group[(41.20±5.51)cm/s vs(34.51±3.09)cm/s](t=7.925,P<0.05). After treatment,in the study group,contraction pressure,contraction duration,class Ⅰ muscle fiber fatigue,Ⅱ muscle fiber fatiguedecreased than those in the control group[(97.58±12.26)cmH2O vs(69.82±8.46)cmH2O,(19.41±1.48)s vs(7.22±1.30)s,(5.51±0.94)% vs(6.85±1.00)%,(5.59±0.87)% vs(6.82±1.05)%](t=13.950,46.310,7.306,6.750,P<0.05). After treatment,the syndrome scores of the study group were lower than those of the control group[main syndrome:(5.24±1.49)points vs(7.82±1.63)points,secondary syndrome:(2.13±0.25)points vs(3.14±0.53)points](t=8.743,12.900,P<0.05). After treatment,the level of PRL in the study group was higher than those in the control group[(388.51±26.25)ng/mL vs(345.65±24.29)ng/mL]and the level of E2 was lower than that of the control group[(515.64±68.47)U/L vs(691.82±85.00)U/L](t=8.968,2.739,12.080,P<0.05). After treatment,the levels of TGF-β3 and RLX decreased than those of the control group[(27.46±4.52)mg/L vs(35.48±4.65)mg/L,(53.22±3.17)μg/L vs(61.42±5.45)μg/L](t=9.255,9.733,P<0.05).

Conclusion

Buzhong Yiqi Granules can promote uterine involution and inhibit TGF-β3 in women with Qideficiency syndrome. RLX secretion can improve lactation function and pelvic floormuscle strength,reduce muscle fiber fatigue,promote uterine involution and postpartum repair in a short time.

parturient women with Qi deficiency syndrome  /  Buzhong Yiqi Granules(补中益气颗粒)  /  lactation function  /  uterine involution  /  pelvic floor function  /  transforming growth factor-β3  /  relaxin
胡婉静, 叶亦巍. 补中益气颗粒对气虚证产妇产后修复情况及转化生长因子β3、松弛素水平的影响. 中华中医药学刊, 2026 , 44 (1) : 93 -97 . DOI: 10.13193/j.issn.1673-7717.2026.01.020
Wanjing HU, Yewei YE. Effects of Buzhong Yiqi Granules(补中益气颗粒)on Postpartum Repair,Levels of TGF-β3 and RLX in Women with Qi Deficiency Syndrome[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (1) : 93 -97 . DOI: 10.13193/j.issn.1673-7717.2026.01.020
Year 2026 volume 44 Issue 1
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doi: 10.13193/j.issn.1673-7717.2026.01.020
  • Online Date:2026-10-14
  • Published:2026-01-10
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    Wenzhou Hospital of Traditional Chinese Medicine, Wenzhou 325000, Zhejiang, China
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表12种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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