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Research Progress on Effects of Acupuncture on Mitochondria in Neurodegenerative Diseases
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Runchen ZHANG1, 2, Yuxuan LI2, 3, Haoming ZHANG1, Wenyi GE1, Yajing MA2, 3, 4, Xinhui CHENG2, 3, 4, Tao LIU2, 3, Can WANG2, 3, Shu WANG1, 2, 5, Yang GUO2, 3, 6
Chinese Archives of Traditional Chinese Medicine | 2026, 44(1) : 82 - 88
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Chinese Archives of Traditional Chinese Medicine | 2026, 44(1): 82-88
• Target on National Project •
Research Progress on Effects of Acupuncture on Mitochondria in Neurodegenerative Diseases
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Runchen ZHANG1, 2, Yuxuan LI2, 3, Haoming ZHANG1, Wenyi GE1, Yajing MA2, 3, 4, Xinhui CHENG2, 3, 4, Tao LIU2, 3, Can WANG2, 3, Shu WANG1, 2, 5, Yang GUO2, 3, 6
Affiliations
  • 1.Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin 300120, China
  • 2.National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300193, China
  • 3.First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
  • 4.Graduate School of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
  • 5.Key Laboratory of Cerebropathy Acupuncture Therapy of State Administration of Traditional Chinese Medicine, Tianjin 300193, China
  • 6.Tianjin Key Laboratory of Acupuncture and Moxibustion, Tianjin 300193, China
Published: 2026-01-10 doi: 10.13193/j.issn.1673-7717.2026.01.018
Outline
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Neurodegenerative diseases，including Alzheimer's disease，Parkinson's disease and Huntington's disease，are major global causes of disability and death worldwide. Protecting mitochondrial function has become a critical therapeutic strategy in managing central nervous system（CNS）disorders. Acupuncture has shown the potential to modulate the biochemical homeostasis in the CNS and maintain the neural stability. This review focuses on the regulatory effects of acupuncture on mitochondrial morphology and function in CNS diseases. Studies have found that acupuncture can improve the ultrastructure of the affected brain regions and regulate the mitochondrial dynamics and plays the key roles in both the synthesis and breakdown of mitochondrial energy. It also mitigates the oxidative stress which is a precursor to many pathogenic mechanisms and modulates the mitochondria-mediated apoptosis and autophagy through multiple pathways and perspectives. Overall，the regulatory effects of acupuncture on mitochondria are multi-targeted and multi-faceted，offering bidirectional modulation capabilities for neurodegenerative diseases.

acupuncture  /  neurodegenerative diseases  /  mitochondrial dynamics  /  autophagy
张润琛, 李昱萱, 张皓茗, 葛文逸, 马雅婧, 程鑫慧, 刘涛, 王璨, 王舒, 郭扬. 针灸对神经系统退行性疾病线粒体影响的研究进展. 中华中医药学刊, 2026 , 44 (1) : 82 -88 . DOI: 10.13193/j.issn.1673-7717.2026.01.018
Runchen ZHANG, Yuxuan LI, Haoming ZHANG, Wenyi GE, Yajing MA, Xinhui CHENG, Tao LIU, Can WANG, Shu WANG, Yang GUO. Research Progress on Effects of Acupuncture on Mitochondria in Neurodegenerative Diseases[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (1) : 82 -88 . DOI: 10.13193/j.issn.1673-7717.2026.01.018
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Year 2026 volume 44 Issue 1
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Article Info
doi: 10.13193/j.issn.1673-7717.2026.01.018
  • Online Date：2026-10-14
  • Published：2026-01-10
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Affiliations
    1.Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin 300120, China
    2.National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300193, China
    3.First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
    4.Graduate School of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
    5.Key Laboratory of Cerebropathy Acupuncture Therapy of State Administration of Traditional Chinese Medicine, Tianjin 300193, China
    6.Tianjin Key Laboratory of Acupuncture and Moxibustion, Tianjin 300193, China
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https://castjournals.cast.org.cn/joweb/zhzyyxk/EN/10.13193/j.issn.1673-7717.2026.01.018
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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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