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Randomized Controlled Trial of Effect of Buzhong Yiqi Decoction（补中益气汤）Combined with TPO-RA on Chemotherapy Induced Thrombocytopenia（Qi and Blood Deficiency Syndrome）
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Minghu DU1, Jianxia HUANG1, Yupei WANG1, Yuqing DONG1, Wanqi GAO1, Yan WANG1, Qing WU1, Binzhang WU1, Chunmei MA2
Chinese Archives of Traditional Chinese Medicine | 2026, 44(1) : 67 - 71
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Chinese Archives of Traditional Chinese Medicine | 2026, 44(1): 67-71
• Target on National Project •
Randomized Controlled Trial of Effect of Buzhong Yiqi Decoction（补中益气汤）Combined with TPO-RA on Chemotherapy Induced Thrombocytopenia（Qi and Blood Deficiency Syndrome）
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Minghu DU1, Jianxia HUANG1, Yupei WANG1, Yuqing DONG1, Wanqi GAO1, Yan WANG1, Qing WU1, Binzhang WU1, Chunmei MA2
Affiliations
  • 1.Wuwei People's Hospital, Wuwei 733000, Gansu, China
  • 2.The Center for Disease Control and Prevention of Minqin County, Minqin 733300, Gansu, China
Published: 2026-01-10 doi: 10.13193/j.issn.1673-7717.2026.01.015
Outline
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Objective

To investigate the clinical efficacy of Buzhong Yiqi Decoction（补中益气汤，BZYQT）combined with thrombopoietin receptor agonists（TPO-RA）in treating thrombocytopenia caused by tumor therapy.

Methods

A total of 160 patients with thrombocytopenia due to tumor therapy were randomly divided into a control group and an experimental group，each consisting of 80 cases. The control group was only given TPO-RA treatment，while the experimental group received BZYQT in combination with TPO-RA. After 8 weeks，the two groups were compared in terms of platelet count，bleeding risk level，Karnofsky performance status（KPS）score，changes in serum thrombopoietin（TPO）content and adverse reactions.

Results

After treatment，both groups showed significant recovery in platelet parameters，bleeding risk，KPS score and serum TPO content. Compared with that of the control group，the overall effectiveness rate of the treatment group reached 95.00%（76/80）. Additionally，the values of platelet count（PLT）and plateletcrit（PCT）of the experimental group were higher than those of the control group（P<0.001），while the values of platelet distribution width（PDW）and mean platelet volume（MPV）were lower（P<0.001）. The improvement in bleeding risk and KPS score was more pronounced in the experimental group than that in the control group（P<0.001）. The serum TPO content in the experimental group was significantly higher than that in the control group（P<0.001），and the number of adverse reaction events decreased.

Conclusion

The combination of BZYQT and TPO-RA in treating thrombocytopenia caused by tumor therapy yields more significant effects and can reduce the adverse reactions caused by TPO-RA to a certain extent.

Buzhong Yiqi Decoction（补中益气汤）  /  TPO-RA  /  thrombocytopenia caused by tumor therapy  /  randomized controlled trial
杜明虎, 黄建霞, 王玉珮, 董玉青, 高万琦, 王燕, 吴庆, 吴彬章, 马春梅. 补中益气汤联合TPO-RA对肿瘤治疗所致血小板减少症（气血不足证）作用的随机对照试验. 中华中医药学刊, 2026 , 44 (1) : 67 -71 . DOI: 10.13193/j.issn.1673-7717.2026.01.015
Minghu DU, Jianxia HUANG, Yupei WANG, Yuqing DONG, Wanqi GAO, Yan WANG, Qing WU, Binzhang WU, Chunmei MA. Randomized Controlled Trial of Effect of Buzhong Yiqi Decoction（补中益气汤）Combined with TPO-RA on Chemotherapy Induced Thrombocytopenia（Qi and Blood Deficiency Syndrome）[J]. Chinese Archives of Traditional Chinese Medicine, 2026 , 44 (1) : 67 -71 . DOI: 10.13193/j.issn.1673-7717.2026.01.015
Appendix
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Year 2026 volume 44 Issue 1
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Article Info
doi: 10.13193/j.issn.1673-7717.2026.01.015
  • Online Date：2026-10-14
  • Published：2026-01-10
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Affiliations
    1.Wuwei People's Hospital, Wuwei 733000, Gansu, China
    2.The Center for Disease Control and Prevention of Minqin County, Minqin 733300, Gansu, China
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https://castjournals.cast.org.cn/joweb/zhzyyxk/EN/10.13193/j.issn.1673-7717.2026.01.015
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表12种不同金属材料的力学参数
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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