To investigate the effect of Qiangxin Decoction（强心汤）combined with Yixin Huazhuo Decoction（益心化浊方）on clinical prognosis and cardiac function of chronic heart failure with Qi deficiency and blood stasis.

A total of 104 patients with chronic heart failure with Qi deficiency and blood stasis admitted to the hospital from March 2021 to January 2023 were selected as research objects. The patients were given random envelopes upon admission and divided into study group and control group with 52 cases in each group according to odd-even simple random method. The control group received conventional Western medicine treatment. Qiangxin Decoction and Yixin Huazhuo Decoction were used for 1 course of treatment（4 weeks），and both groups were treated for 2 courses of treatment. The clinical efficacy，TCM symptom scores before and after treatment，cardiac function indexes［N terminal brain natriuretic peptide（NT-pro BNP），left ventricular end-diastolic diameter（LVEDD），left ventricular end-systolic diameter（LVESD），left ventricular ejection fraction（LVEF）］，vascular endothelial cell function［endothelin-1（ET-1），nitric oxide（NO）］and adverse reactions in the two groups were compared.

The total effective rate of the study group was 80.77%（42/52），which was significantly higher than that of the control group（61.54%，32/52），with statistical significance（P<0.05）. After treatment，the scores of shortness of breath，palpitation，chest tightness，chest pain and lower limb edema were significantly lower in both groups than those before treatment（P<0.05），and those in the study group were significantly lower than those in the control group（P<0.05）. After treatment，the levels of LVEDD，LVESD and NT-proBNP in both groups were lower than those before treatment，and the levels of the study group were significantly lower than those of the control group（P<0.05）. The levels of LVEF in both groups were higher than those before treatment，and the level of LVEF of the study group was higher than that of the control group（P<0.05）. After treatment，the levels of NO in both groups were significantly higher than those before treatment，the levels of ET-1 were significantly lower than those before treatment，and the change in the study group was more obvious than that in the control group（P<0.05），and there was no significant difference in the occurrence of adverse reactions between the two groups during treatment（P>0.05）.

Qiangxin Decoction combined with Yixin Huazhuo Decoction can significantly improve the therapeutic effect and cardiac function of patients with chronic heart failure with Qi deficiency and blood stasis and has a high safety，suitable for popularization and application.