To explore the clinical efficacy of Sangju Qingjie Decoction（桑菊清解汤）combined with symptomatic and supportive therapy including anti-infection，antipyretic therapy，fluid resuscitation and aerosol inhalation in children with lobar pneumonia.

A total of 198 children with lobar pneumonia were classified into two groups，each with 99 cases. The control group was given symptomatic supportive treatment such as anti-infection，antipyretic therapy，fluid replenishment and aerosol inhalation，while the observation group was given Sangju Qingjie Decoction on the basis of the control group. The levels of high-sensitivity C-reactive protein（hs-CRP），white blood cells（WBC），erythrocyte sedimentation rate（ESR），interleukin-6（IL-6），peak expiratory flow（PEF），forced respiratory volume in 1 second（FEV1）and FEV1 versus forced vital capacity（FEV1/FVC）were compared between the two groups before and after treatment. Meantime，the time of fever reduction，the disappearance time of cough，sputum and wheezing，and hospital stay length，clinical efficacy and adverse reaction rate were also observed in both groups.

The total efficacy rate in the observation group（97.98%，97/99）was higher than that in the control group（84.85%，84/99）with statistical difference（P<0.05）. The TCM syndrome scores including cough，wheezing，expectoration and wheezing yielded no statistical difference between two groups before treatment（P>0.05），and the scores were descended in two groups after treatment（P<0.05）. There were statistical difference before and after treatment in two groups（P<0.05）. After treatment，TCM syndromes score of the observation group was lower than that of the control group（P<0.05）. The observation group had descended time to fever reduction，cough disappearance，sputum disappearance，wheezing disappearance and hospital stay length compared with the control group（P<0.05）. The levels of IL-6，WBC，hs-CRPand ESR of two groups before treatment showed no statistical difference（P>0.05），and had statistical difference after treatment（P<0.05）. After treatment，the levels of IL-6，WBC，hs-CRPand ESR were lower in the observation group than those of the control group（P<0.05）. No statistical difference was found in FEV1，PEF or FEV1/FVC before treatment（P>0.05），while the post-treatment FEV1，PEF and FEV1/FVCdenoted statistical difference with those before treatment（P<0.05）. The three pulmonary function indicators were higher in the observation group than those of the control（P<0.05）. After treatment，the total adverse reaction rate was 5.05%（5/99）in the observation group，which was slightly lower than that of the control group（7.07%，7/99）（P>0.05）.

The application of Sangju Qingjie Decoction combined with symptomatic and supportive therapy including anti-infection，antipyretic therapy，fluid resuscitation and aerosol inhalation in children with lobar pneumonia can remarkably improve the clinical outcome in children by shortening the duration of treatment，cutting down the rate of adverse reaction，and improving lung function and the serum levels of inflammatory factors.