To explore the clinical effect of Modified Juanbi Decoction（蠲痹汤加减）combined with thunder-fire moxibustion at Dazhui（DU14）in the treatment of cervical spondylosis.

A total of 120 patients with cervical spondylosis（cold-dampness blocking collateral type）admitted from September 2022 to September 2023 were included in the study. The patients were divided into the conventional group and the traditional Chinese medicine group by random number table method，with 60 cases in each group. The conventional group was treated with Celecoxib Capsule，while the traditional Chinese medicine group was treated with Celecoxib Capsule and Modified Juanbi Decoction combined with thunder-fire moxibustion at Dazhui（DU14）. During the study，4 cases fell off in the conventional group and 3 cases fell off in the traditional Chinese medicine group. The data of each group，including clinical treatment efficacy，the traditional Chinese medicine syndrome scores（neck and shoulder pain and numbness，chest tightness，headache，nausea，upper limb heaviness，etc.）before and after treatment，serum the levels of transforming growth factor-β1（TGF-β1），interleukin-1β（IL-1β）and tumor necrosis factor alpha（TNF-α），the changes of cervical physiological curvature and pain scale（visual analog scale，VAS）scores，the cervical spondylosis（CASCS）scores and neck disability index（NDI）scores and adverse reactions were observed and compared.

The total effective rate of the traditional Chinese medicine group（96.49%，55/57）was higher than that of the conventional group（85.71%，48/56）（P<0.05）. After treatment，the TCM syndrome scores（neck and shoulder pain and numbness，chest tightness，headache，nausea，upper limb heaviness，etc.），the levels of TGF-β1，IL-1βand TNF-αand VASscores were all decreased in both groups，physiological curvature indexes of cervical vertebra were increased，CASCSscores and NDI scores were improved. The above indexes in the traditional Chinese medicine group were lower than those in the conventional group，and the physiological curvature of cervical spine was higher than that in the conventional group，CASCSscores and NDI scores were higher than those in the conventional group（P<0.05）. The adverse reaction rate of the traditional Chinese medicine group（1.75%，1/57）was lower than that of the conventional group（12.50%，7/56）（P<0.05）.

Modified Juanbi Decoction combined with thunder-fire moxibustion at Dazhui（DU14）in the treatment of cervical spondylosis（cold-dampness blocking collateral type）has good clinical effect，with improved symptoms and better cervical function recovery，and the treatment is safe and reliable.