Full
Outline
To study the clinical effect of Anshen Jiaotai Yizhi Decoction（安神交泰益智汤）in the treatment of Parkinson's disease with sleep disorders and its effect on the levels of homocysteine（Hcy）and interleukin-1β（IL-1β）in patients.
110 patients with Parkinson's disease and sleep disorders were selected and divided into two groups，55 patients in the control group were treated with western medicine，and 55 patients in the observation group were treated with western medicine combined with Anshen Jiaotai Yizhi Decoction. After 2 weeks of treatment，the clinical efficacy，sleep quality，sleep structure index，related factor levels and adverse reactions were compared.
The total effective rate of the observation group（96.36%，53/55）was higher than that（83.64%，46/55）of the control group（P<0.05）. The Epworth sleepiness scale（ESS）scores after 2 weeks of treatment of the observation group was（7.92±1.83）points，and that of the control group was（9.14±2.11）points（P<0.05）. The sleep efficiency of the two groups increased，the sleep latency shortened，the number of awakenings decreased，the apnea hypopnea index（AHI）decreased，and the minimum oxygen saturation increased. The indexes of the observation group were significantly better than those of the control group［（78.89±6.20）%，（23.10±4.08）min，（1.97±0.56）times，（9.08±1.03），（89.15±5.80）% vs（73.39±6.14）%，（27.82±5.26）min，（2.75±0.67）times，（11.71±1.34），（86.30±5.52）%］（P<0.05）. The levels of serum Hcy and IL-1βin the two groups decreased，and the levels of the observation group were significantly lower than those in the control group［（1.01±0.06）mg/L，（8.90±1.85）pg/mL vs（1.20±0.06）mg/L，（10.13±1.91）pg/mL］（P<0.05）. The incidence of adverse reactions of the two groups had no significance（14.55%，8/55 vs 10.91%，6/55）（P>0.05）.
Anshen Jiaotai Yizhi Decoction has a better clinical effect in the treatment of Parkinson's disease with sleep disorders. It can significantly improve sleep status and regulate the neuroimmune inflammatory response in the brain. It is a safe and effective treatment plan and is worthy of application.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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