Full
Outline
To explore the effects of Xionggui Zhitong Decoction（芎归止痛汤）combined with carbamazepine on pain，sleep，inflammatory factors and oxidative stress in patients with primary trigeminal neuralgia（PTN）.
A hundred cases of PTN patients were randomly divided into observation group and study group（50 cases in each group）. The two group were treated with carbamazepine，and the study group was treated with Xionggui Zhitong Decoction on the basis of carbamazepine. The changes of pain，sleep，inflammatory factors and oxidative stress before and after treatment were observed.
The present pain intensity score（PPI），pain rating index score（PRI）and visual analogue scale（VAS）score，Pittsburgh Sleep Quality Index（PSQI）score，the levels of serum substance P（SP），vasoactive intestinal peptide（VIP），tumor necrosis factor-α（TNF-α），interleukin-6（IL-6），interleukin-1β（IL-1β）and malondialdehyde（MDA）of the two groups after treatment were lower than those before treatment（P<0.05），the levels ofβ-endorphin（β-EP），superoxide dismutase（SOD）and glutathione peroxidase（GSH-Px）were higher than those before treatment（P<0.05）. After treatment，the scores of PPI，PRI，VASand PSQI scores，the levels of serum SP，VIP，TNF-α，IL-6，IL-1βand MDA in the study group were lower than those in the control group（P<0.05），and the levels ofβ-EP，SOD and GSH-Px in the study group were higher than those in the control group（P<0.05）. The therapeutic effect of the study group was better than that of the control group（P<0.05）.
Xionggui Zhitong Decoction combined with carbamazepine in the treatment of primary trigeminal neuralgia can help to improve the pain and sleep status of patients，reduce the levels of inflammatory factors and oxidative stress，and improve the clinical therapeutic effect.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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