Full
Outline
To investigate the effects of Tianxiong Dingxuan Decoction（天芎定眩汤）combined with citicoline on TCM syndrome and cerebral hemodynamics in elderly patients with post-circulation ischemic vertigo of phlegm and blood stasis obstructing orifices type.
A total of 96 elderly patients with post-circulation ischemic vertigo of phlegm and blood stasis obstructing orifices type from March 2021 to December 2023 in the Department of Encephalopathy of Zhanjiang Second Hospital of Traditional Chinese Medicine were selected as the study objects. According to different treatment plans，they were divided into study group and control group，with 48 cases in each group. The control group received conventional Western medicine treatment such as citicoline. The study group was treated with Tianxiong Dingxuan Decoction on the basis of the control group. Both groups were treated for 2 weeks. The changes of TCM syndrome scores，Dizziness Handicap Inventory（DHI）score，cerebral hemodynamic indexes（flow velocity of basilar artery，left vertebral artery and right vertebral artery），plasma viscosity，whole blood viscosity and fibrinogen level were compared before and after treatment between the two groups. The efficacy of the two groups after 2 weeks and the adverse reactions during treatment were compared.
After treatment，the scores of dizziness，nausea and vomiting，fatigue，tinnitus and deafness and clouded heavy head，DHI score，the levels of plasma，whole blood viscosity and fibrinogen were significantly decreased in both groups，and the results of the study group were significantly lower than those of the control group（P<0.05）. After treatment，the cerebral blood flow velocity in the study group was significantly higher than that in the control group（P<0.05）. The total effective rate of the study group was significantly higher than that of the control group（P<0.05）. There was no significant difference in adverse reactions between the two groups during treatment（P>0.05）.
Tianxiong Dingxuan Decoction combined with citicylcholine can significantly improve the TCM symptoms and cerebral hemodynamic indexes of elderly patients with post-circulation ischemic vertigo of phlegm and blood stasis obstructing orifices type. It has accurate efficacy and high safety，and is worthy of promoting in the treatment of integrated traditional Chinese and Western medicine.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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