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Shaoyao Decoction（芍药汤）Inhibits Development and Metastasis of Colorectal Cancer by Promoting ROS Dependent Autophagy
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Ruihang ZHANG1, 2, SHAN Zengzhuoga1, MIMA Zhuoga3, Xiwen ZHANG4, Yupeng XI4, Zhenhua ZHANG4, Xiaoyan WANG1, 2, 3
Chinese Archives of Traditional Chinese Medicine | 2025, 43(11) : 172 - 176
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Chinese Archives of Traditional Chinese Medicine | 2025, 43(11): 172-176
• Target on National Project •
Shaoyao Decoction（芍药汤）Inhibits Development and Metastasis of Colorectal Cancer by Promoting ROS Dependent Autophagy
Full
Ruihang ZHANG1, 2, SHAN Zengzhuoga1, MIMA Zhuoga3, Xiwen ZHANG4, Yupeng XI4, Zhenhua ZHANG4, Xiaoyan WANG1, 2, 3
Affiliations
  • 1.Xizang University of Tibetan Medicine，Lhasa 850000，Xizang，China
  • 2.Wangjing Hospital，China Academy of Chinese Medical Sciences，Beijing 100102，China
  • 3.Tibetan Hospital in Xizang Autonomous Region，Lhasa 850000，Xizang，China
  • 4.Guang'anmen Hospital，China Academy of Chinese Medical Sciences，Beijing100053，China
Published: 2025-11-10 doi: 10.13193/j.issn.1673-7717.2025.11.034
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Objective

Shaoyao Decoction（芍药汤）is expected to be a candidate prescription for the treatment of colorectal cancer，but its underlying mechanism and molecular targets remain to be explored.

Methods

A mouse model of colorectal cancer transplantation was established，and 30 mice were divided into 3 groups：model group（M，n＝10），model＋Shaoyao Decoction group（SYD，n＝10）and model＋Shaoyao Decoction＋ROSclearance group（SNR，n＝10）. The mice of the SYD group were given 37 g/kg Shaoyao Decoction by gavage，the mice of the SNR group were given an equal amount of Shaoyao Decoction after intraperitoneal injection of ROSclearance agent，and those of the M group were given the same amount of distilled water. The drug was administered continuously for 21 days. The body weight and tumor volume of mice were observed，ROSlevels in tumors were detected by fluorescence method，and the protein expression in autophagy pathway was detected by western blot.

Results

Shaoyao Decoction inhibited the growth of transplanted colorectal cancer in mice，induced ROSaccumulation in tumor tissues，up-regulated the expressions of Beclin-1，LC3，BIP，PERK and ATG5 proteins，down-regulated the expression of p62 protein，and inhibited the expressions of proteins in PI3K/AKT/mTOR signaling pathway.

Conclusion

Shaoyao Decoction can induce autophagy by promoting excessive accumulation of reactive oxygen species，thus inhibiting the growth of colorectal cancer transplant tumors.

Shaoyao Decoction（芍药汤）  /  colorectal cancer  /  autophagy
张瑞航, 单增卓嘎, 米玛卓嘎, 张曦文, 席玉棚, 张振华, 王晓燕. 芍药汤通过促进活性氧依赖性自噬以抑制结直肠癌发展和转移. 中华中医药学刊, 2025 , 43 (11) : 172 -176 . DOI: 10.13193/j.issn.1673-7717.2025.11.034
Ruihang ZHANG, SHAN Zengzhuoga, MIMA Zhuoga, Xiwen ZHANG, Yupeng XI, Zhenhua ZHANG, Xiaoyan WANG. Shaoyao Decoction（芍药汤）Inhibits Development and Metastasis of Colorectal Cancer by Promoting ROS Dependent Autophagy[J]. Chinese Archives of Traditional Chinese Medicine, 2025 , 43 (11) : 172 -176 . DOI: 10.13193/j.issn.1673-7717.2025.11.034
Appendix
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Year 2025 volume 43 Issue 11
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doi: 10.13193/j.issn.1673-7717.2025.11.034
  • Online Date：2026-10-30
  • Published：2025-11-10
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Affiliations
    1.Xizang University of Tibetan Medicine，Lhasa 850000，Xizang，China
    2.Wangjing Hospital，China Academy of Chinese Medical Sciences，Beijing 100102，China
    3.Tibetan Hospital in Xizang Autonomous Region，Lhasa 850000，Xizang，China
    4.Guang'anmen Hospital，China Academy of Chinese Medical Sciences，Beijing100053，China
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https://castjournals.cast.org.cn/joweb/zhzyyxk/EN/10.13193/j.issn.1673-7717.2025.11.034
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
Number of
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Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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