Full
Outline
To analyze the effect of Modified Baitouwen Decoction（加味白头翁汤）on the level of autophagy protein in patients with liver cancer after surgery.
Ninety-two patients with liver cancer admitted to the Department of Hepatobiliary and pancreatic Surgery of Shanxi Cancer Hospital were included as the study objects，and were selected from March 2022 to September 2024. They were divided into two groups by random number table method. Forty-six patients in the control group received surgical treatment，and 46 patients in the observation group received combined treatment with Modified Baitouwen Decoction on the basis of the control group. The therapeutic effect，TCM symptom scores，liver function indexes，tumor markers and related autophagy protein level were compared between the two groups.
The objective remission rate and disease control rate in the observation group were 43.48%（20/46）and 93.48%（43/46），respectively，which were higher than 31.91%（15/46）and 73.91%（34/46）in the control group（P<0.05）. After treatment，the TCM symptom scores of the observation group were lower than those of the control group（P<0.05）. After treatment，the levels of alanine aminotransferase（ALT），aspartate aminotransferase（AST）and total bilirubin（TBIL）in the observation group were lower than those in the control group，and the level of albumin（ALB）was higher than that in the control group，with significant difference between two groups（P<0.05）. After treatment，the levels of alpha fetoprotein isoform3（AFP-L3），Golgi apparatus protein 73（GP73），alpha fetoprotein（AFP）and gamma glutamyltransferase（γ-GT）in the observation group were lower than those in the control group，and the positive rates of microtubule associated protein 1 light chain 3（LC3），Beclin-1 and mammalian target protein of rapamycin（mTOR）were lower than those in the control group，with significant differences between the two groups（P<0.05）.
Modified Baitouwen Decoction has a clear therapeutic effect on patients with liver cancer after surgery，which can alleviate the relevant symptoms of patients，protect liver function，reduce the levels of tumor markers，regulate the levels of LC3，Beclin-1 and mTOR，inhibit the proliferation of cancer cells and delay the development of disease，and has high application value.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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