Full
Outline
To analyze the effects of Qilong Capsule（芪龙胶囊）combined with edaravone dextrocamphorol and butylphthalein on serum amyloid protein（SAA），glial fibrillary acidic protein（GFAP），ubiquitin-carboxy-terminal hydrolase 1（UCH-L1）and nerve function in patients with acute cerebral infarction.
Ninety patients with acute cerebral infarction admitted to the hospital from202201 to 202401 were divided into the control group（45 cases）and the combination group（45 cases）by random number table method.The control group was treated with edaravone dextrocamphorol and butylphthalein，and the combined group was treated with Qilong Capsule combined with edaravone dextrocamphorol and butylphthalein for 2 weeks.Traditional Chinese medicine syndrome scores，serum levels of SAA，GFAP and UCH-L1，cerebral blood perfusion，neurological function before treatment，1 and 2 weeks after treatment，and the safety during treatment were compared between the two groups.
During the intervention period，2 cases fell off in the combined group and 1 case fell off in the control group.Compared with those before treatment，after 2 weeks of treatment，the scores of pale complexion，awkward speech，hemiplegia，shortness of breath and fatigue and the serum levels of SAA，GFAP and UCH-L1 in the two groups were lower and those in the combined group were significantly lower than those of the control group（P<0.05）.The National Institutes of Health Stroke Scale（NIHSS）score of the two groups showed a decreasing trend before treatment，1 and 2 weeks after treatment，and the score of the two groups was significantly lower in the combination group（P<0.05）.Compared with those before treatment，after 2 weeks of treatment，the end diastolic blood flow velocity（EDV），peak systolic flow velocity（PSV）and mean velocity（Vm）of middle cerebral artery in the two groups increased，and the levels were significantly higher in the combined group（P<0.05）.During treatment，none of the subjects stopped treatment due to adverse reactions，and the incidence of adverse reactions was similar between the two groups（P>0.05）.
Qilong Capsule combined with edaravone dextrocamphorol and butaphthalein can improve traditional Chinese medicine syndrome scores and nerve function in patients with acute cerebral infarction.The possible mechanism is to regulate the expressions of SAA，GFAPand UCH-L1，control the nerve cell injury and improve the cerebral blood perfusion，with good safety.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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