Full
Outline
To explore and analyze the potential quality markers（Q-markers）of Baizhi（Angelicae Dahuricae Radix）combined with fingerprint and network pharmacology methods based on the primary principles of Q-markers.
The similarity evaluation and common peaks identification were performed by establishing fingerprints of Baizhi（Angelicae Dahuricae Radix），and then the“active ingredient-target-pathway”network was constructed to predict the key targets and core components of Baizhi（Angelicae Dahuricae Radix）through the network pharmacology.Meanwhile，the integrative analysis of Q-markers of Baizhi（Angelicae Dahuricae Radix）from the perspectives of chemical composition validity，measurability and so forth based on current literatures.
Ten batches of fingerprints of Baizhi（Angelicae Dahuricae Radix）were established，10 common peaks were identified，and 4 peaks（byakangelicol，imperatorin，phellopterin，isoimperatorin）were identified by reference substances.In accordance with network analysis，the above four coumarins were its main bioactive compounds with high connectivity.Byakangelicol，imperatorin，phellopterin and isoimperatorin could be further clarified as the potential Q-markers of Baizhi（Angelicae Dahuricae Radix）according to the Q-marker concept.
The preliminary prediction and analysis of the Qmarkers of Baizhi（Angelicae Dahuricae Radix）provides a theoretical basis for further study on pharmacodynamics and pharmacological mechanism，which can militate in favor of whole quality control system of Baizhi（Angelicae Dahuricae Radix）.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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