To investigate the effect of Danggui Shaoyao Powder（当归芍药散）combined with levofloxacin on clinical symptoms and matrix metalloproteinase-2/9（MMP-2/9）levels in patients with endometritis.

One hundred and twelve patients with endometritis in Reproductive Medicine Department of the hospital from January 2019 to January 2021 were enrolled and divided into two groups according to different treatment methods.The control group（52 cases）received levofloxacin therapy，while the observation group（60 cases）received Danggui Shaoyao Powder combined with levofloxacin.Then the comparison was conducted on serum inflammatory factors，MMP-2/9 levels，Visual Analogue Scale（VAS）score，Female Sexual Function Index（FSFI）score，sex hormone levels，clinical pregnancy outcome，the disappearance time of pelvic pain，leucorrhea and pelvic inflammation，the clinical efficacy and incidence of adverse reactions.

The levels of interleukin-4（IL-4），interleukin-6（IL-6），C-reactive protein（CRP），MMP-9 and MMP-2 at baseline yielded no statistical difference（P>0.05），while the above inflammation factors were significantly decreased in the observation group compared with those in the control group after treatment（P<0.05）.The scores of VASand FSFI yielded no statistical difference between two groups before treatment（P>0.05），while the observation group scored lower in VASand FSFI than the control group after treatment（P<0.05）.The disappearance time of pelvic pain，leucorrhea and pelvic inflammation was significantly shorted in the observation group compared with that in the control group（P<0.05）.The overall efficacy rate was 91.67%（55/60）in the observation group，which was significantly higher than 76.92%（40/52）in the control group，with statistical difference（χ²＝4.703，P=0.030）.The total adverse reaction rate was 5.00%（3/60）in the observation group，which was slightly lower than 7.69%（4/52）in the control group，with no statistical difference（χ²＝0.344，P=0.557）.The abortion rate was 0.00%（0/60）in the observation group，which was slightly lower than 1.92%（1/52）in the control group，with no statistical difference（χ²＝1.164，P=0.280）.The timing of pregnancy shortened in the observation group compared with that in the control group（P<0.05），and the clinical pregnancy rate was 83.00%（50/60）in the observation group，and was higher than 59.62%（31/52）in the control group，with statistical difference（χ²＝7.828，P=0.005）.The ectopic pregnancy rate was 0.00% in both groups，with no statistical difference.

The application of Danggui Shaoyao Powder combined with levofloxacin in the treatment of endometritis can effectively attenuate the inflammation response，down-regulate the serum levels of MMP-2/9，accelerate the disappearance time of pelvic pain and leucorrhea，reduce the levels of sex hormones，ameliorate the infertility symptoms，decrease the adverse reactions and improve the quality of life in patients.