To observe the clinical efficacy and safety of Xiangsha Wenzhong Decoction（香砂温中汤）combined with acupoint thread-embedding in the intervention for chronic atrophic gastritis（CAG）with Helicobacter pylori（HP）infection.

A total of 160 patients with CAG and Hp infection who were admitted to the hospital from January 2022 to June 2023 were enrolled in this study.They were randomly divided into group A，group B，group Cand group D using the random number table method.Group A was treated with acupoint thread-embedding.Group B was treated with Xiangsha Wenzhong Decoction.Group Cwas treated with acupoint thread-embedding combined with Xiangsha Wenzhong Decoction.Group D was treated with teprenone.The 4 groups were compared in terms of clinical efficacy，TCM syndrome scores，gastric mucosal histopathological score，endothelial function［epidermal growth factor（EGF）and vascular endothelial growth factor（VEGF）］，inflammatory factors［interleukin-6（IL-6）and tumor necrosis factor-α（TNF-α）］，cellular immune function，expression of cyclooxygenase-2（COX-2）and p53 in gastric mucosa，and the incidence of adverse reactions.

The total effective rate of group C（95.00%，38/40）was higher than that of group A，group B and group D［70.00%（28/40），75.00%（30/40）and 62.50%（25/40）］（P<0.05）.The total effective rates in group A，group Band group D were close（P>0.05）.After 6 months of treatment，TCM syndrome scores and gastric mucosal histopathological score of group Cwere lower than those of group A，group B and group D（P<0.05），but there was no significant difference among group A，group B and group D（P>0.05）.After 6 months of treatment，the levels of VEGF，CD3⁺and CD4⁺in group Cwere higher than those in group A，group B and group D.The levels of EGF，IL-6，TNF-αand CD8⁺were lower than those in group A，group B and group D（P<0.05）.However，there was no significant difference among group A，group B or group D（P>0.05）.After 6 months of treatment，the expressions of COX-2 and p53 in group C were lower than those in group A，group B and group D（P<0.05），but there was no significant difference among group A，group B and group D（P>0.05）.There was no significant difference in the incidence of adverse reactions among the four groups（P>0.05）.

Xiangsha Wenzhong Decoction combined with acupoint thread-embedding is significantly effective in the treatment of patients with CAG and Hp infection.It can improve the patients’symptoms and endothelial function，reduce the levels of inflammatory factors，enhance the immune function and down-regulate the expressions of COX-2 and p53，with high safety.