Full
Outline
Malignant tumor is a disease that seriously endangers human health.Angiogenesis is one of the important mechanisms of the occurrence and development of malignant tumors.Vascular endothelial growth factor（VEGF）is widely regarded as the main regulator of angiogenesis and plays an extremely important role in the process of angiogenesis.Targeting VEGF and vascular endothelial growth factor receptor（VEGFR）can reduce angiogenesis in tumor and help to inhibit tumor invasion，proliferation and metastasis，which is one of the important fields of medical research.Natural compounds are widely defined as chemical substances produced by organisms，which have unique chemical diversity，wide sources，multi-targets，multi-mechanisms，multi-channels，low toxic and side effects.Modern studies have confirmed that natural compounds exert an anti-tumor effect on inhibiting angiogenesis by inhibiting VEGF，and natural compounds have obvious therapeutic advantages for malignant tumors，which can effectively inhibit the occurrence and development of tumors and improve the quality of life of cancer patients.In this paper，the related research of natural compounds on anti-angiogenesis and anti-tumor through inhibiting VEGF was summarized，and the main mechanism of VEGF/VEGFR signaling pathway was combed，so as to provide reference for the optimization of clinical malignant tumor treatment strategy.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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