Full
Outline
To observe the clinical effectof Ziyin Xiehuo Prescription（滋阴泻火方）on girlswith precocious puberty and simple obesity.
A total of230 girlswith central precocious puberty accompanied by simple obesity admitted from June 2020 to June2023 were included in the study. The patients were divided into control group and observation group by random number table method，with 115 cases in each group. The girls in the control group were treated with leuprorelin acetate microspheres，while those in the observation group were treated with leuprorelin acetate microspheres combined with Ziyin Xiehuo Prescription. The treatment lasted for 6months. During the treatment，5 cases fell off in the observation group and 4 cases fell off in the controlgroup. The data of allgroupswas compared，including the efficacy，traditional Chinese medicine syndrome score before treatment and 6 months after treatment，the levels of serum estradiol（E2），luteinizing hormone（LH）and follicle-stimulating hormone（FSH），uterine length and ovarian volume，breast stage，bone age，body mass index（BMI）and adverse reactions.
The total effective rate of girls in the observation group was higher than that in the control group. Before treatment，the traditional Chinese medicine syndrome scores，the levels of E2，LH and FSH，uterine length，ovarian volume，breast stage，bone age and BMI of all groupswere not significant（P>0.05）. After treatment，the traditional Chinese medicine syndrome scores，the levels of E2，LH and FSH，uterine length，ovarian volume and breast stage of girls in both groupswere decreased（P<0.05）. After treatment，the levels of traditional Chinese medicine syndrome scores，the levels of E2，LH and FSH in the observation group were lower than those in the control group，the values of uterine length，ovarian volume，breast stage and bone age were lower than those in the control group，and BMI in the observation group was lower than that in the control group. The adverse reaction rate of girls in observation group and controlgroup was low（P>0.05）.
In the treatment of central precocious puberty with simple obesity girls，Ziyin Xihuo Prescription can regulate the levels of sex hormones，delay the development of breast，uterus and ovary，do not aggravate the trend of obesity，and inhibit the growth of bone age to a certain extent.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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