Full
Outline
Podocyte is one of the important components of glomerular filtration barrier. Its injury can cause a variety of glomerular diseases. Repairing or improving podocyte injury is a potential target for the treatment of a variety of glomerular diseases and has received extensive attention. The key pathological mechanisms are mainly related to oxidative stress，autophagy disorder，inflammatory response，epithelial-mesenchymal transition，mitochondrial dysfunction，endoplasmic reticulum stress and abnormal expression of podocytemarker proteins. Podocyte injury belongs to“kidney source”in TCM，which is the syndrome of deficiency in root and excess in branch. Huangqi（Astragali Radix）can treat podocyte injury by tonifying kidney and replenishing Qi to strengthen the healthy Qi and expelling toxin to eliminate the pathogenic factors. It can regulate autophagy，improve mitochondrial dysfunction and regulate the expressions of podocytemarker proteins to reinforce the healthy Qi. It can regulate anti-oxidative stress，inhibit inflammatory response，inhibitepithelial-mesenchymal transition，and down-regulate endoplasmic reticulum stress to eliminate the pathogenic factors. It plays a role in protecting podocytes inmultiple pathways and multiple targets. This article reviewed the research status of the mechanism of Huangqi（Astragali Radix）and its active ingredients in the intervention of podocyte injury，aiming to provide a certain reference for the clinical application of Huangqi（Astragali Radix）in the treatment of podocyte injury and to prospect the future research direction.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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