To evaluate the impact of Yougui Pill（右归丸）and Modified Ditan Decoction（涤痰汤）on endocrine hormone metabolism and insulin resistance in the treatment of polycystic ovary syndrome（PCOS）.

A total of 102 patients with PCOSadmitted to the hospital from March 2020 to March 2024 were selected as the study objects，51 cases in the control group were treated with Western medicine alone，and a total of 51 patients in the observation group received treatment with Yougui Pill and Modified Ditan Decoction based on the standard therapy，and the clinical effects，sex hormone indexes，ovarian and menstrual conditions，and glucose metabolism indexes of the two groups were compared.

The total effective rate of the observation group was 98.04%，higher than 78.43% of the control group，and the difference was significant（P<0.05）. After treatment，the serum levels of testosterone（T）and luteinizing hormone（LH）in the two groups were lower than those before treatment，and the levels of estradiol（E2），prolactin（PRL），follicle-stimulating hormone（FSH）and sex hormone binding globulin（SHBG）were higher than those before treatment（P<0.05），and the decrease/increase in the observation group was more significant than that in the controlgroup（P<0.05）. After treatment，the ovarian volume and follicle number of the two groupswere increased（P<0.05），and the increase was more significant in the observation group compared with that in the control group（P<0.05）. The recovery rate of menstruation in the observation group was96.08%，which was higher than that（74.51%）in control group（P<0.05）. The ovarian recovery rate of the observation group was 96.08%，higher than that of the control group（76.47%，P<0.05）. After treatment，the levels of fasting blood glucose（FBG），fasting insulin（FINS），2-hour blood glucose（2 h PG）and insulin resistance index（HOMA-IR）in both groups were decreased（P<0.05）. Compared with those in the control group，the levels of FBG，FINS，2 h PG and HOMA-IR in the observation group were significantly decreased（P<0.05）.

In patients with PCOS，the combined treatment with medication and the approach of warming kidney and resolving phlegm demonstrates the significant therapeutic efficacy. This regimen effectively regulates the endocrine hormone levels，improves the glucose metabolism parameters and facilitates the recovery of the patients.