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Research Progress on clinical Application and Pharmacological Mechanism of Sini Powder（四逆散）
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Zhiyi WANG1, 2, Ziyang HUANG1, 2, Zibo LI1, 2, Erping XU1, 2
Chinese Archives of Traditional Chinese Medicine | 2025, 43(9) : 91 - 98
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Chinese Archives of Traditional Chinese Medicine | 2025, 43(9): 91-98
• Target on National Project •
Research Progress on clinical Application and Pharmacological Mechanism of Sini Powder（四逆散）
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Zhiyi WANG1, 2, Ziyang HUANG1, 2, Zibo LI1, 2, Erping XU1, 2
Affiliations
  • 1.Collaborative Innovation Center of Research and Development on The Whole Industry Chain of Yu Medicine，Zhengzhou 450046，Henan，China
  • 2.Academy of Traditional Chinese Medicine，Henan University of Chinese Medicine，Zhengzhou 450046，Henan，China
Published: 2025-09-10 doi: 10.13193/j.issn.1673-7717.2025.09.016
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Sini Powder（四逆散），a renowned formula from ZHANG Zhongjing’s Shanghan Lun in the Han Dynasty. Its main functions are to dispel evils and relieve depression and soothe liver and regulate spleen. Its medicinal attributes，therapeutic efficacy and sophisticated formulation are all centered on the principle of“harmonizing”. As a classic prescription，Sini Powder exhibits extensive clinical potential and significant research value regarding its mechanism of action. With the advancement of traditional Chinese medicine within the realm ofmodernmedical science，Sini Powder has shown considerable progress in both clinical applications and mechanistic understanding. It is extensively utilized in addressing neurological disorders，gastrointestinal diseases，gynecological conditions and other medical fields，demonstrating notable therapeutic efficacy. From a pharmacological perspective，Sini Powder exerts a range of activities，including antidepressant，sedative-hypnotic，hepatoprotective，antineoplastic and anti-inflammatory effects，characterized by its multi-target and multi-pathway therapeutic approach. This review synthesized recent studies by domestic and international researchers on the clinical applications and mechanisms of Sini Powder，thereby providing amore robust scientific foundation for its clinical use.

Sini Powder（四逆散）  /  clinical application  /  mechanism of action  /  research progress
王志一, 黄梓洋, 李自波, 许二平. 四逆散临床应用及药理机制研究进展. 中华中医药学刊, 2025 , 43 (9) : 91 -98 . DOI: 10.13193/j.issn.1673-7717.2025.09.016
Zhiyi WANG, Ziyang HUANG, Zibo LI, Erping XU. Research Progress on clinical Application and Pharmacological Mechanism of Sini Powder（四逆散）[J]. Chinese Archives of Traditional Chinese Medicine, 2025 , 43 (9) : 91 -98 . DOI: 10.13193/j.issn.1673-7717.2025.09.016
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Year 2025 volume 43 Issue 9
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doi: 10.13193/j.issn.1673-7717.2025.09.016
  • Online Date：2026-10-30
  • Published：2025-09-10
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    1.Collaborative Innovation Center of Research and Development on The Whole Industry Chain of Yu Medicine，Zhengzhou 450046，Henan，China
    2.Academy of Traditional Chinese Medicine，Henan University of Chinese Medicine，Zhengzhou 450046，Henan，China
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表12种不同金属材料的力学参数
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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