Full
Outline
To explore the preventive effect of Ziyin Yishen Decoction（滋阴益肾汤）on postoperative cerebral vasospasm（CVS）in perimenopausal female patients with intracranial aneurysms undergoing interventional therapy，and the influence of the levels of serum vascular cell adhesion molecule 1（sVCAM-1）and soluble intercellular adhesion molecule-1（sICAM-1）.
Sixty perimenopausal female patients with intracranial aneurysms who underwent microsurgery in the hospital from July 2021 to March 2023 were divided into the control group（30 cases）and the observation group（30 cases）. The control group was treated with nimodipine，while the observation group additionally received Ziyin Yishen Decoction on the basis of the control group. The treatment course for two groups was 14 days. The treatment efficacy and postoperative CVS incidence between two groupswere compared. Before and after treatment，the BI score and NIHSS score，the levels ofmiddle cerebral artery blood flow velocity（VMCA）and endothelin-1（ET-1）as well as the levels of serum sVCAM-1 and sICAM-1 were evaluated.
The effective rate of the observation group was higher than that of the control group（P<0.05）. The incidence of postoperative CVS in the observation group was lower than that of the control group（P<0.05）. After treatment，BIscore and the level of VMCA of two groups were higher than those before treatment，while the NIHSS score，the levels of ET-1，sVCAM-1 and sICAM-1 were lower than those before treatment（P<0.05）. BIscore and the level of VMCA of the observation group were higher than those of the control group，while the NIHSS score，the levels of ET-1，sVCAM-1 and sICAM-1 were lower than those of the control group（P<0.05）.
Ziyin Yishen Decoction has a significant therapeutic effecton perimenopausal female patients undergoing interventional therapy for intracranial aneurysms. It can reduce the occurrence of postoperative CVSand lower the serum levels of sVCAM-1 and sICAM-1，worthy of clinical reference.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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