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Review on Immune Inflammation Mechanism of Acupotomy in Knee Osteoarthritis
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Yuqian YANG1, Xiaole WANG2, Qiguang CAO2, Ting FANG2, Biao DENG1, Jinchao ZHU1, Fushui LIU1, 2
Chinese Archives of Traditional Chinese Medicine | 2025, 43(9) : 66 - 72
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Chinese Archives of Traditional Chinese Medicine | 2025, 43(9): 66-72
• Target on National Project •
Review on Immune Inflammation Mechanism of Acupotomy in Knee Osteoarthritis
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Yuqian YANG1, Xiaole WANG2, Qiguang CAO2, Ting FANG2, Biao DENG1, Jinchao ZHU1, Fushui LIU1, 2
Affiliations
  • 1.Jiangxi University of Chinese Medicine，Nanchang 330000，Jiangxi，China
  • 2.Affiliated Hospital of Jiangxi University of Chinese Medicine，Nanchang 330000，Jiangxi，China
Published: 2025-09-10 doi: 10.13193/j.issn.1673-7717.2025.09.011
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This review summarized the effects of acupotomy therapy on the mechanism of immune inflammation in knee osteoarthritis. Knee osteoarthritis has become a worldwide problem due to its high disease rate and disability rate. Acupotomy therapy is unique amongmany therapies because of its characteristics of efficiency，convenience and economy. With the deepening of research，it is found that the acupotomy may regulate inflammatory factors in the treatment of knee osteoarthritis：（1）regulating pro-inflammatory factors，such as pro-inflammatory factors such as tumor necrosis factor-α（TNF-α），interleukin（IL）and so on；inducing nuclear factor-kB（NF-kB），Janus kinase（JAK）/signal transducer and activator of transcription（STAT），phosphatidylinositol 3-kinase（PI3K）/protein kinase B（AKT），mitogen-activated protein kinase（MAPK）and other signaling pathways to reduce inflammatory response；（2）regulating anti-inflammatory factors，such as interleukin-4（IL-4），interleukin-10（IL-10），to affect the JAK/STAT and PI3K/AKT signaling pathway to produce anti-inflammatory effects. In conclusion，by sorting out the mechanism of immune inflammatory and the intervention of acupotomy therapy in knee osteoarthritis，it provided more evidence and thoughts for the treatment of knee osteoarthritis.

acuputomy  /  inflammation  /  knee osteoarthritis  /  immune  /  review
杨煜乾, 王小乐, 曹奇光, 方婷, 邓彪, 朱金超, 刘福水. 针刀干预膝骨关节炎免疫炎症机制的研究进展. 中华中医药学刊, 2025 , 43 (9) : 66 -72 . DOI: 10.13193/j.issn.1673-7717.2025.09.011
Yuqian YANG, Xiaole WANG, Qiguang CAO, Ting FANG, Biao DENG, Jinchao ZHU, Fushui LIU. Review on Immune Inflammation Mechanism of Acupotomy in Knee Osteoarthritis[J]. Chinese Archives of Traditional Chinese Medicine, 2025 , 43 (9) : 66 -72 . DOI: 10.13193/j.issn.1673-7717.2025.09.011
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Year 2025 volume 43 Issue 9
36
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doi: 10.13193/j.issn.1673-7717.2025.09.011
  • Online Date：2026-10-30
  • Published：2025-09-10
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    1.Jiangxi University of Chinese Medicine，Nanchang 330000，Jiangxi，China
    2.Affiliated Hospital of Jiangxi University of Chinese Medicine，Nanchang 330000，Jiangxi，China
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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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