To evaluate the effect of the combination of clearing heat，promoting blood circulation and treating phlegm and blood stasis methods with N-acetylcysteine on serum inflammatory factors and sex hormones in polycystic ovary syndrome（PCOS）.

A total of 120 patients with PCOSwho received diagnosis and treatment were selected.Survey data was randomly divided into equal proportion groups，with 60 cases in each group.The control group received N-acetylcysteine.The observation group was treated with Yikang Decoction（抑亢汤）combined with N-acetylcysteine.Both groups continued treatment for 3 months.After the intervention，the efficacy of both groups was evaluated and inflammatory factors such as hypersensitive C-reactive protein（hs-CRP），interleukin-6（IL-6）and tumor necrosis factor-α（TNF-α），hormones［follicle stimulating hormone（FSH），luteinizing hormone（LH）and estradiol（E2）］，insulin resistance index（HOMA-IR），body mass index（BMI）and waist to hip ratio（WHR）before and after 3 months of treatment were measured.

The effective rate of the observation group was better than that of the control group，and the difference was statistically significant（P<0.05）.After 3 months of intervention，the levels of serum hs-CRP，IL-6 and TNF-αin the observation group were lower than those of the control group and the difference was statistically significant（P<0.05）.After 3 months of intervention，the serum LH level in the observation group was lower than that in the control group，and the difference was statistically significant（P<0.05）.After 3 months of intervention，the values of HOMA-IR，BMI and WHR in the observation group were lower than those in the control group，with statistically significant differences（P<0.05）.

The combination of clearing heat，promoting blood circulation and treating phlegm and blood stasis methods with N-acetylcysteine has a definite therapeutic effect on PCOS，inhibiting inflammatory factors and improving endocrine function and various metabolic indicators.It is worthy of vigorously promoting in clinical practice.