To analyze the effect of Qingre Lishi Decoction（清热利湿汤）combined with Babaodan（八宝丹）in the treatment of hemorrhoids with dampness-heat pouring down syndrome and its influence on inflammation and immune response.

A hundred and two patients with hemorrhoids from June 2020 to April 2023 were selected as the research objects.The patients were divided into study group and control group by random number table method，with 51 cases in each group.The control group was given Babaodan，and the study group was given Qingre Lishi Decoction on the basis of the control group.The effect was evaluated after continuous treatment for 8 weeks in both groups.TCM symptom scores，improvement of main symptoms and clinical efficacy were compared between the two groups.Changes of inflammatory factors and immune response factors in peripheral blood were compared between the two groups.Adverse reactions of the two groups were recorded during treatment.

The TCM syndrome scores of the main and secondary symptoms of two groups after treatment were lower than those before treatment（P<0.05），and the scores of the study group after treatment were lower than those of the control group（P<0.05）.The disappearance time of bleeding，anal swelling and anal pain in the study group were shorter than those in the control group（P<0.05）.The total effective rate of the study group was higher than that of the control group（P<0.05）.The serum levels of interferon-γ（IFN-γ），interleukin-4（IL-4）and interleukin-17（IL-17）in two groups after treatment were lower than those before treatment（P<0.05）.The levels of IFN-γ，IL-4 and IL-17 in the study group after treatment were lower than those of the control group（P<0.05）.The levels of immunoglobulin G（IgG），IgM，C3 and C4 in two groups after treatment were higher than those before treatment（P<0.05），and the levels of IgG，IgM，C3 and C4 in the study group after treatment were higher（P<0.05）.There were no obvious adverse reactions in both groups during treatment.

In the treatment of hemor-rhoids with dampness-heat pouring down syndrome，Qingre Lishi Decoction combined with Babaodan can enhance the therapeutic effect，reduce the levels of inflammatory factors and improve the immune response function，with good safety.