To study the therapeutic effect of traditional Chinese medicine（TCM）on nasosinusitis induced by radiotherapy of nasopharyngeal carcinoma（NPC）and its effect on the indexes of hypersensitive C-reactive protein（hs-CRP），interleukin-17（IL-17）and tumor necrosis factor-α（TNF-α）.

From December 2019 to November 2022，108 patients with nasosinusitis caused by radiotherapy of spleen-stomach deficiency，dampness-heat invading the upper syndrome and lung-stomach Yin deficiency and evil toxin retention syndrome were selected and divided into two groups according to different treatment methods.The patients in the routine treatment group were treated with saline rinse and roxithromycin orally.The TCM syndrome differentiation group was combined with TCM syndrome differentiation treatment on the basis of routine treatment and analyzed the clinical curative effect of the two groups after treatment.

The total effective rate was 96.30%（52/54）in the TCM syndrome differentiation group and 85.19% （46/54）in the routine treatment group.The total effective rate of the patients in the TCM syndrome differentiation group was higher than that in the routine treatment group（P<0.05）.The levels of hs-CRP，IL-17 and TNF-αin the two groups before treatment were compared between the two groups.The difference was not statistically significant（P>0.05）.After treatment，the levels of hs-CRP，IL-17 and TNF-αin TCM syndrome differentiation group were lower than those in the routine treatment group（P<0.05）.There was no significant difference in cilia transmission rate，Lund-Mackay score or pain score between two groups before treatment（P>0.05）.After treatment，the cilia transmission rate in the TCM syndrome differentiation group was（4.58±0.61）mm/min，higher than that in the routine treatment group.The Lund-Mackay score［（3.89±0.54）points］and the pain score［（1.14±0.75）points］in the TCM syndrome differentiation group were lower than those in the routine treatment group（P<0.05）.

The treatment of nasosinusitis caused by radiotherapy of NPCby TCM syndrome differentiation can inhibit the expressions of inflammatory factors，improve the cilia transmission rate，alleviate the pain degree of patients and improve the therapeutic effect.