To explore the effect of Xiaojia Decoction（消瘕汤）combined with denogestrin on sexual hormone levels and ovarian function in patients with adenomyosis.

Ninety patients with kidney deficiency and blood stasis type of adenomyosis who were treated in the hospital from January 2021 to December 2022 were collected and randomly divided into A group and B group，with 45 patients in each group.Group A was treated with dinoprotein，while Group B was treated with Xiaojia Decoction combined with dinoprotein.The treatment effects，traditional Chinese medicine symptom scores，sex hormone levels and serum indicators were compared between the two groups.

The effective rate of treatment in Group B was significantly higher than that in Group A（P<0.05）.After treatment，the scores of menstrual cycle，menstrual volume，menstrual abdominal pain，mental depression，chest and flank fullness and tongue purple dark in Group B were significantly lower than those before treatment（P<0.05），and the scores of Group B were significantly lower than those of Group A（P<0.05）.After treatment，the levels of testosterone（T），follicle stimulating hormone（FSH）and luteinizing hormone（LH）in Group B were significantly lower than those before treatment（P<0.05），and the levels of Group B were significantly lower than those of Group A（P<0.05）.The level of estradiol（E₂）was significantly higher than that before treatment（P<0.05），and the level of Group B was significantly higher than that of Group A（P<0.05）.After treatment，the levels of matrix metalloproteinase-9（MMP-9），vascular endothelial growth factor（VEGF）and matrix metalloproteinase-2（MMP-2）in Group B were significantly lower than those before treatment（P<0.05），and the levels of group B were significantly lower than those of Group A（P<0.05）.

The combina-tion of Xiaojia Decoction and dinoregestone has good clinical efficacy in treating patients with adenomyosis，which is beneficial for slowing down the progression of adenomyosis，regulating the levels of sexual hormones in patients，improving ovarian function and effectively alleviating clinical symptoms.