Full
Outline
Mitochondria are important organelles of the cell and the sites where the cell produces energy. Studies have shown that mitochondria have the ability to induce apoptosis，and mitochondria-targeted therapy is a new tumor treatment with potential ability. Tumor mortality rate is increasing year by year，seriously threatening people＇s physical and mental health. Clinical and fundamental research studies have already proved that Chinese medicine is effective in tumor treatment，and its advantages of low toxicity and high efficiency，multi-pathway and multi-targeting have made it more and more popular in the clinic. Chinese medicine monomer saponins，such as ginsenoside，escin，α-hederin，Polyphyllin，Platycodin D and so on，can induce apoptosis of tumor cells by endogenous pathway through the regulation of mitochondria，promotion of the expressions of Bax，caspases，cytochrome Cand inhibition of the expression of the Bcl-2 family of proteins，thus exerting an anti-tumor effect. In this paper，it summarized and screened the research results on the regulation of mitochondrial apoptosis by monomer saponins of traditional Chinese medicine in recent years，and took mitochondrial apoptosis as the starting point to introduce the mechanism of mitochondrial apoptosis in detail by monomer saponins of Chinese medicine with a view to exploring the new direction of Chinese medicine in the field of tumor therapy，and helping to promote the modernization of traditional Chinese medicine in the development of the field of tumor therapy.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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