To investigate the effect of ultrasound interventional radiofrequency ablation combined with Lianqi Decoction（莲芪煎剂）on the short-term clinical efficacy，tumor marker levels and immune function indexes of patients with primary liver cancer.

A total of 90 patients with primary liver cancer who were treated in the hospital from June 2018 to June 2020 were retrospectively selected as the research subjects. According to the different treatment plans of the patients，they were divided into a routine group and an observation group with 55 cases in each group. The routine group was treated with radiofrequency ablation，and the observation group was treated with Lianqi Decoction on the basis of the routine group. The short-term efficacy，expression levels of serum T lymphocyte subsets，expression levels of serum seed bulb markers，liver function，liver hardness and safety of the two groups were observed and compared.

The short-term clinical total effective rate of the observation group was significantly higher than that of the conventional group（P<0.05）. After treatment，the levels of alpha fetoprotein（AFP），carcinoembryonic antigen（CEA）and carbohydrate antigen 199（CA199）in the observation group were significantly lower than those in the conventional group（P<0.05）. After treatment，the levels of CD₃⁺ and CD₄⁺ in the observation group were higher than those in the conventional group，and CD₈⁺ was lower than those in the conventional group（P<0.05）. After treatment，the levels of alanine transaminase（ALT），aspartate transaminase（AST）and total bilirubin（TBIL）in the observation group were lower than those in the conventional group（P<0.05）. The incidence of total adverse reactions in the observation group was significantly lower than that in the conventional group（P<0.05）. After treatment，the liver stiffness measurernents（LSM）value of the observation group was better than that of the conventional group（P<0.05）. The patients in the observation group were better than those in the conventional group at 2 years follow-up（P<0.05）.

Ultrasound interventional radiofrequency ablation combined with Lianqi Decoction has better short-term clinical treatment effect on patients with primary liver cancer，which can significantly improve the expression levels of tumor markers，liver elasticity and liver function，and has a good clinical effect. application prospects.